ArticleFrontiers in endocrinology2025
Associations between non-traditional lipid parameters and normoglycemic reversion in Chinese adults with prediabetes: a retrospective analysis.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The association between residual cholesterol to high-density lipoprotein cholesterol ratio and type 2 diabetes risk in elderly populations.Frontiers in endocrinology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Prediabetes is a critical precursor to type 2 diabetes and poses an increasing global health challenge, particularly in China. While many individuals with prediabetes can revert to normoglycemia through lifestyle interventions, the impact of non-traditional lipid parameters on this process requires further investigation. Understanding the associations between these lipid parameters and glycemic recovery could inform more effective prevention strategies. Methods: This study analyzed data from the Dryad public database, focusing on a cohort of 14,735 Chinese adults with prediabetes. Multivariate logistic regression models assessed the association between twelve lipid parameters and normoglycemia. Two-piecewise logistic regression was used to identify inflection points. Stratified and sensitivity analyses were conducted by age, sex, BMI, and family history of diabetes. The Area Under the Curve was calculated to compare predictive performance. Results: During a mean follow-up of 2.94 years, 6,406 out of 14,735 participants with prediabetes (56.53%) reverted to normoglycemia. Multivariate logistic regression showed that lower levels of the atherogenic index of plasma (AIP), remnant cholesterol (RC), RC/HDL-C ratio, and LDL-C, as well as higher HDL-C, were significantly associated with a higher likelihood of normoglycemia. Except for HDL-C, all lipid parameters showed non-linear relationships with normoglycemia. While all lipid indices displayed modest discriminative ability (AUC > 0.5), AIP demonstrated the highest area under the curve (AUC = 0.579, 95% CI: 0.569-0.588). Subgroup and sensitivity analyses confirmed stronger associations in females, younger individuals (< 50 years), and those with lower BMI (< 24 kg/m²). Conclusion: AIP, RC, and the RC/HDL-C ratio were strongly associated with reversion to normoglycemia among Chinese adults with prediabetes. AIP showed the strongest and most consistent relationship, especially in younger females with lower BMI.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.