Evidence map›Paper›PMID 40630320›Full record

ArticleKidney international reports2025

The Discrepancy Between Estimated GFR Cystatin C and Estimated GFR Creatinine at 3 Months After Hospitalization and Long-Term Adverse Outcomes.

Yumeng Wen, Nityasree Srialluri, Danielle Farrington, Heather Thiessen-Philbrook, Steven Menez, Dennis G Moledina, Steven G Coca, T Alp Ikizler, Eddie Siew, Alan Go and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Yumeng WenDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nityasree SrialluriDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Danielle FarringtonDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Heather Thiessen-PhilbrookDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Steven MenezDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Dennis G MoledinaSection of Nephrology, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Steven G CocaDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
T Alp IkizlerDivision of Nephrology, Vanderbilt University, Nashville, Tennessee, USA.
Eddie SiewDivision of Nephrology, Vanderbilt University, Nashville, Tennessee, USA.
Alan GoKaiser Permanente Division of Research, Oakland, California, USA.
Chi-Yuan HsuKaiser Permanente Division of Research, Oakland, California, USA.
Jonathan HimmelfarbKidney Research Institute, University of Washington, Seattle, Washington, USA.
Vernon ChinchilliDepartment of Statistics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
James KaufmanDivision of Nephrology, New York University Grossman School of Medicine and VA New York Harbor Healthcare System, New York, New York, USA.
Paul L KimmelNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Amit X GargInstitute for Clinical Evaluation Sciences, Toronta, Ontario, Canada.
Morgan E GramsWelch Center of Prevention, Epidemiology and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Chirag R ParikhDivision of Nephrology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The prognostic value of the discrepancy between the estimated glomerular filtration rate (eGFR) using cystatin C (eGFRcys) and creatinine (eGFRcr) in recently hospitalized adults remains poorly understood. Methods: We characterized the difference between eGFRcys and eGFRcr, at 3 months after discharge, in 1534 hospitalized adults; 767 (50%) with acute kidney injury (AKI) matched 1:1 with patients who did not develop AKI. We used survival analysis to determine the associations between having lower eGFRcys than eGFRcr with risk of end-stage kidney disease (ESKD), major atherosclerotic cardiac events (MACE), heart failure hospitalization, and death after a a median follow-up of 4.7 years. Results: The mean age of study participants was 65.8 years, and 37.3% were female. At 3 months after hospitalization, the median (interquartile range [IQR]) eGFRcr and eGFRcys were 71.5 (51.9-92.6) and 50.5 (34.1-71.9) ml/min per 1.73 m Conclusion: Our findings suggest that the eGFRcys-eGFRcr discrepancy may serve as a valuable prognostic marker in recently hospitalized patients, informing risk stratification and potential interventions.

Indexed as

acute kidney injurycystatin CeGFR assessment

Identifiers

PMID40630320
PMCPMC12230997

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.