ArticleCureus2025
Serum Leptin Is Low and Linked to Obesity and Insulin Resistance in Bangladeshi Youth-Onset Type 2 Diabetes Patients: A Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Background Youth-onset type 2 diabetes mellitus (T2DM) is an escalating global public health concern, mostly driven by increasing obesity and insulin resistance. Leptin, a key adipokine regulating appetite, energy balance, and metabolism, has been implicated in the pathogenesis of diabetes. However, its role in youth-onset T2DM remains unclear, with conflicting findings. Objective This study aimed to measure and compare circulating leptin levels between Bangladeshi young individuals with a clinical diagnosis of new-onset T2DM and normal glucose tolerance (NGT), and to investigate the associations of leptin with obesity markers, glycemic parameters, and insulin resistance. Methods This cross-sectional study involved 36 youth (aged 13-30 years) with a clinical diagnosis of new-onset T2DM and 36 age-matched individuals with NGT attending the young diabetes clinic of Bangladesh Medical University (BMU), Bangladesh, during 2017-2018. Anthropometric measurements were recorded, and fasting blood samples were analyzed for glucose, insulin, and leptin levels by glucose-oxidase, chemiluminescent immunoassay, and enzyme-linked immunosorbent assay, respectively. Insulin resistance was assessed by the homeostasis model assessment-insulin resistance (HOMA-IR). Body mass index (BMI) was calculated and both the T2DM and NGT groups were dichotomized to non-obese (including normal weight and underweight; for adults, BMI <23 kg/m
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