Evidence map›Paper›PMID 40630435›Full record

ReviewReviews in cardiovascular medicine2025

Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease.

Xiao-Lu Zhang, Tian-Peng Wei, Fan Yang, Huan-Huan Liu, Ling-Ling Qian, Ru-Xing Wang

Abstract readReview
In one paragraph

Review in Reviews in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Late IMedicinal research reviews · 2026
    Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiao-Lu ZhangDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 214023 Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0008-1201-0958
Tian-Peng WeiDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 214023 Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0007-8068-1473
Fan YangDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 214023 Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0002-2260-5476
Huan-Huan LiuWuxi School of Medicine, Jiangnan University, 214122 Wuxi, Jiangsu, China.ORCID https://orcid.org/0009-0000-9560-4971
Ling-Ling QianDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 214023 Wuxi, Jiangsu, China.ORCID https://orcid.org/0000-0003-0317-5589
Ru-Xing WangDepartment of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, 214023 Wuxi, Jiangsu, China.ORCID https://orcid.org/0000-0001-7355-5048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI)-related arrhythmias are an essential risk factor in sudden cardiac death. Aberrant cardiac the cardiac voltage-gated sodium channel (Nav1.5) is important in the development of ventricular arrhythmias after an MI. These mechanisms are profoundly complex and involve sodium voltage-gated channel α subunit 5 (

Indexed as

arrhythmiamyocardial infarctionNav1.5SCN5A

Identifiers

PMID40630435
PMCPMC12230830

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.