ArticlebioRxiv : the preprint server for biology2025
Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The second meal phenomenon refers to the improved glycemic response observed after consuming a second identical meal. It is well known that postprandial hepatic glucose uptake (HGU) is determined by the combined effects of three regulatory factors: insulin action (hyperinsulinemia; HI), glucose effectiveness (hyperglycemia; GE), and glucose delivery into the hepatoportal circulation (portal glucose signal; PGS). While our previous studies demonstrated the importance of morning (AM) hyperinsulinemia in priming the liver for increased HGU later in the day, the question remains as to which aspect of the afternoon (PM) response is enhanced by morning insulin. Thus, to provide insight into the underlying mechanism of the 2
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