ArticlebioRxiv : the preprint server for biology2025
Assessing the Rate-Dependence of the First Phase of Glucose-Stimulated Insulin Secretion: Dynamic Perifusion Studies with Isolated Human Pancreatic Islets.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Insulin released in response to a stepwise increase in glucose (square wave) is biphasic with a transient first-phase peak of 5-10 min and a more sustained second phase. While it is usually assumed that the first phase is rate- and the second is concentration-dependent, there are no detailed investigations into the rate-sensitivity of the first phase. We performed dynamic perifusion studies with isolated human pancreatic islets in a system that allowed fully customizable glucose ramps and established the corresponding insulin secretion time-profiles with high (once-a-minute) time-resolution. We considered the first-phase release to be the excess amount of insulin in addition to what would be expected from the glucose concentration-dependent second-phase release and examined its dependence on the glucose gradient (rate of increase). The average first-phase insulin release rate calculated this way increased with the gradient and could be fitted well with a Hill-type sigmoid function having a half-maximal value around 1.25 mM/min (
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