Evidence map›Paper›PMID 40631502›Full record

ArticleJournal of cachexia, sarcopenia and muscle2025

Novel Algorithm to Estimate Fat-Free Muscle Volumes in Women Using the Urinary Deuterated-Creatine Dilution Method.

Darren Yuen Zhang Tan, Wei Fun Cheong, Shanshan Ji, Amaury Cazenave-Gassiot, Jane Cauley, Liang Shen, Eu-Leong Yong

Abstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Darren Yuen Zhang TanDepartment of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
Wei Fun CheongDepartment of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
Shanshan JiSingapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.
Amaury Cazenave-GassiotSingapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore, Republic of Singapore.
Jane CauleyDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Liang ShenBiostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.
Eu-Leong YongDepartment of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Republic of Singapore.ORCID 0000-0001-6511-770X

Funding

Singapore National Medical Research Council CSASI20nov-0006Singapore National Medical Research Council MOH-000670-01
6 · The paper itself

Abstract

backgroundMuscle mass declines after menopause and is a key risk factor for frailty, falls and poor physical function as women age. The deuterated creatine (D

methodsThe Integrated Women's Health Programme (IWHP) enrolled 1201 healthy community-dwelling women, aged 45-69 years at baseline, who attended gynaecological clinics from 2014 to 2016. Between February 2021 and July 2023, 894 participants were recontacted, and 451 of the respondents agreed to ingest 30 mg of D

resultsParticipants (n = 451, mean age 62.6 ± 5.9) were randomly divided into training (n = 367) and validation (n = 84) cohorts. In the training cohort, stepwise multivariable regression modelling indicated that age (β = -0.011, p = 0.076) and ethnicity (β = 0.154, p = 0.317 [Indian]; β = -0.012, p = 0.942 [Malay] compared to Chinese) were not associated with fat-free muscle volumes. In the final model, D

conclusionsMuscle volumes estimated with the D

Indexed as

AlgorithmsCreatineMuscle, SkeletalAgedDeuteriumFemaleHumansMagnetic Resonance ImagingMiddle AgedCreatineDeuteriumbody compositioncreatinecreatinineMRImuscle masssarcopenia

Identifiers

PMID40631502
PMCPMC12238901

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.