SynthesisInternational journal of urology : official journal of the Japanese Urological Association2025
Efficacy of Metastasectomy for Metastatic Bladder Cancer: A Systematic Review and Meta-Analysis.
Synthesis in International journal of urology : official journal of the Japanese Urological Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metastasis-Directed Surgery for Solitary Pulmonary Metastasis After Pembrolizumab in Urothelial Carcinoma: A Case Report.IJU case reports · 2026Article
- [Indication and outcome of salvage surgery for urogenital malignancies].Urologie (Heidelberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivesIt has been proposed that metastasectomy may cure some patients with a single metastasis. Hence, we considered it necessary to clarify the role of metastasectomy for metastatic bladder cancer (BCa).
methodsWe conducted a systematic review of published reports on the efficacy of metastasectomy for different sites of BCa metastasis. We searched English articles published before 7 June 2025 in three electronic databases: PubMed, Embase, and Cochrane Library. We then extracted authors, year of publication, country in which the study was conducted, study institution, study design, survival analysis, months of follow-up, size of study cohort, treatment, hazard ratios (HR) with 95% confidence interval (CI), and source of HR. The Newcastle-Ottawa Scale was used to analyze the risk and quality of included studies. All procedures were performed according to the PRISMA guidelines. A meta-analysis was performed on studies with sufficient survival data to analyze. Overall survival was analyzed to clarify the efficacy of metastasectomy for metastatic BCa.
resultsOur meta-analysis identified 8 of 7877 articles published from 1992 to 2024 that met our criteria. These articles encompassed 15 139 patients in all, which showed that patients who underwent metastasectomy had better overall survivals (OS) than did those who only had non-surgical treatment (HR = 0.46, 95% CI 0.27-0.79, I
conclusionsWe found a positive association between metastasectomy and OS in patients with metastatic BCa, especially those with brain metastases. Metastasectomy should be considered an adequate approach in BCa, when feasible.
trial registrationPROSPERO number: CRD42021234305.
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Registered trials
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