Evidence map›Paper›PMID 40632522›Full record

ArticleMolecular biology of the cell2025

The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling during

Jonathon M Thomalla, Michelle S Giedt, Roger P White, Israel J Wipf, Alicia Shipley, Minhao Chen, Michael A Welte, Tina L Tootle

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jonathon M ThomallaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca 14853, NY.ORCID 0000-0003-3968-4764
Michelle S GiedtDepartment of Biology, University of Iowa, Iowa City 52242, IA.ORCID 0000-0002-5720-8326
Roger P WhiteDepartment of Biology, University of Rochester, Rochester 14627, NY.ORCID 0000-0001-5648-4719
Israel J WipfDepartment of Biology, University of Iowa, Iowa City 52242, IA.ORCID 0000-0003-1105-0786
Alicia ShipleyDepartment of Biology, University of Iowa, Iowa City 52242, IA.ORCID 0009-0006-9346-7380
Minhao ChenDepartment of Biology, University of Rochester, Rochester 14627, NY.
Michael A WelteDepartment of Biology, University of Rochester, Rochester 14627, NY.ORCID 0000-0001-5741-4720
Tina L TootleDepartment of Biology, University of Iowa, Iowa City 52242, IA.ORCID 0000-0002-1515-9538

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
TRAINING PROGRAM IN FREE RADICAL AND RADIATION BIOLOGYT32CA078586 · NCI · UNIVERSITY OF IOWA · PI SPITZ, DOUGLAS ROBERT · 1999 to 2024
$5.7M
Lipid droplets as protein sequestration sitesR01GM102155 · NIGMS · UNIVERSITY OF ROCHESTER · PI WELTE, MICHAEL ANDREAS · 2013 to 2025
$4.2M
Predoctoral Training in the Pharmacological SciencesT32GM067795 · NIGMS · UNIVERSITY OF IOWA · PI STRACK, STEFAN · 2004 to 2021
$3.4M
Prostaglandins and actin remodelingR35GM144057 · NIGMS · UNIVERSITY OF IOWA · PI Tina L Tootle · 2022 to 2026
$2.1M
Predoctoral Training in the Pharmacological SciencesT32GM144636 · NIGMS · UNIVERSITY OF IOWA · PI David L. Roman, STEFAN STRACK · 2022 to 2026
$1.9M
Prostaglandins control development by coordinating actin cytoskeletal remodelingR01GM116885 · NIGMS · UNIVERSITY OF IOWA · PI TOOTLE, TINA L · 2016 to 2020
$1.6M
How calcium triggers the transition from egg to embryoR01HD114777 · NICHD · CORNELL UNIVERSITY · PI Mariana Federica Wolfner · 2025 to 2026
$671k
Determining the Role of the Conserved TRPM Ion Channel in Egg Activation, Using the Drosophila ModelR03HD101732 · NICHD · CORNELL UNIVERSITY · PI WOLFNER, MARIANA FEDERICA · 2020 to 2021
$155k
NCI NIH HHS T32 CA078586NICHD NIH HHS R01 HD114777NICHD NIH HHS R03 HD101732NIGMS NIH HHS R01 GM102155NIGMS NIH HHS R01 GM116885NIGMS NIH HHS R35 GM144057NIGMS NIH HHS T32 GM067795NIGMS NIH HHS T32 GM144636NIH HHS P40 OD018537
6 · The paper itself

Abstract

Growing evidence supports that lipid droplets (LD) are critical for producing high-quality oocytes. However, the functions of LDs during oocyte development remain largely unknown. Using

Indexed as

ActinsDrosophila ProteinsOogenesisProstaglandinsActin CytoskeletonAnimalsDrosophila melanogasterFemaleLipaseLipid DropletsOocytesSignal TransductionActinsDrosophila ProteinsLipaseProstaglandins

Identifiers

PMID40632522
PMCPMC12415609

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.