Evidence map›Paper›PMID 40632560›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The pathogenic factor of ZC4H2-associated rare disorder is a postsynaptic regulator for synaptic activity and cognitive function.

Li Pear Wan, Yuwei Li, Shuhua Zhao, Shiping Zhao, Ning-Ning Song, Kai-Ming Yuan, Cuiping Yang, Yu-Qiang Ding, Bingyu Mao, Nengyin Sheng and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Li Pear Wan *Fujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, China.ORCID 0000-0001-8661-0659
Yuwei Li *State Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.
Shuhua ZhaoFirst Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China.
Shiping ZhaoState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.ORCID 0009-0004-2517-3474
Ning-Ning SongLaboratory Animal Resources Center, Fudan University, Shanghai 200032, China.
Kai-Ming YuanDepartment of Anesthesiology and Perioperative Medicine, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.ORCID 0000-0002-9660-8218
Cuiping YangThe International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, School of Medicine, Shanghai Jiao-Tong University, Shanghai 200030, China.ORCID 0000-0001-5277-4321
Yu-Qiang DingLaboratory Animal Resources Center, Fudan University, Shanghai 200032, China.ORCID 0000-0003-1202-4635
Bingyu MaoState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.ORCID 0000-0002-7993-3158
Nengyin ShengState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.ORCID 0000-0003-3086-3950
Wucheng TaoFujian Key Laboratory of Translational Research in Cancer and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, China.ORCID 0000-0003-2577-8161
Pengcheng MaState Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, Yunnan, China.ORCID 0000-0002-1067-8021

Funding

National Key R&D Program of China 2023YFA1800500National Natural Science Foundation of China 32371017
6 · The paper itself

Abstract

The maintenance of excitatory synaptic activity is crucial for cognitive function and genetic mutations are responsible for the pathogenesis of related brain disorders. However, the roles of these pathogenic factors in synaptic dysregulation and cognitive malfunction are still poorly understood. In this study, a conditional knockout mouse model lacking

Indexed as

CognitionIntellectual DisabilitySynapsesAnimalsDisease Models, AnimalHumansLong-Term PotentiationMiceMice, KnockoutNeuronal PlasticityNeuronsReceptors, AMPASynaptic TransmissionReceptors, AMPAAMPA receptorexcitatory synaptic activityintellectual disabilityperampanelZC4H2

Identifiers

PMID40632560
PMCPMC12280958

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.