Evidence map›Paper›PMID 40632653›Full record

ArticleCell reports2025

Testosterone and 17β-estradiol regulate hippocampal area CA3 sharp waves in male and female rats.

Patrice Pearce, John J LaFrancois, Vanessa Skucas, Daniel Friedman, André A Fenton, Dino Dvorak, Neil J MacLusky, Helen E Scharfman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrice PearceThe Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; New York University Grossman School of Medicine, New York, NY 10016, USA.
John J LaFrancoisThe Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Vanessa SkucasThe Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Daniel FriedmanNew York University Grossman School of Medicine, New York, NY 10016, USA.
André A FentonNew York University Grossman School of Medicine, New York, NY 10016, USA; New York University, New York, NY 10012, USA.
Dino DvorakNew York University Grossman School of Medicine, New York, NY 10016, USA; Gilgamesh Pharmaceuticals, New York, NY 10003, USA.
Neil J MacLuskyUniversity of Guelph, Guelph, ON, Canada.
Helen E ScharfmanThe Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: helen.scharfman@nki.rfmh.org.

Funding

BDNF AND HIPPOCAMPAL HYPEREXCITABILITYR01NS037562 · NINDS · NATHAN S. KLINE INSTITUTE FOR PSYCH RES · PI SCHARFMAN, HELEN E · 1999 to 2010
$2.6M
Commercializing digital wireless telemetry: the animal epilepsy monitoring unitR42NS064474 · NINDS · BIO-SIGNAL GROUP CORPORATION · PI FENTON, ANDRE ANTONIO · 2008 to 2009
$666k
NINDS NIH HHS R01 NS037562NINDS NIH HHS R42 NS064474
6 · The paper itself

Abstract

Sharp wave-ripples (SPW-Rs) are critical to hippocampal function, and the same is true of gonadal steroids, but the interactions are unclear. We find that surgical removal of the gonads greatly reduces SPW rates in both sexes. Ripples are greatly reduced also. Testosterone treatment rescues SPW and ripple rates in males, and 17β-estradiol restores SPW rates in females. We also find that male SPW rates are higher than females but have less power. Furthermore, in intact females, SPW rates fluctuate with the stage of the ovarian cycle. These data demonstrate that hippocampal SPWs are significantly affected by gonadal removal, testosterone, and 17β-estradiol. In addition, there are sex differences. The data are consistent with past demonstrations that testosterone and 17β-estradiol play central roles in hippocampus and significantly expand the views of hormone action and SPW-Rs.

Indexed as

CA3 Region, HippocampalEstradiolTestosteroneAnimalsFemaleHippocampusMaleRatsRats, Sprague-DawleySex CharacteristicsEstradiolTestosteroneandrogenCP: NeuroscienceEEGestrogenestrous cyclegonadectomyhormonememoryorchidectomyovariectomysex differences

Identifiers

PMID40632653
PMCPMC12335218

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.