ArticlePloS one2025
A retrospective analysis from NHANES 2003-2018 on the associations between inflammatory markers and coronary artery disease, all-cause mortality and cardiovascular mortality.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Association of anxiety, depressive symptoms, and inflammatory indices with cardiometabolic multimorbidity.Brain, behavior, & immunity - health · 2026Article
- Early Inflammatory Biomarkers, Ventricular Dysfunction and In-Hospital Mortality in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention.Diagnostics (Basel, Switzerland) · 2026Article
- Immunological impact of age and comorbidities: findings from the REALISM and SENIOR-HLA-DR cohorts.Aging clinical and experimental research · 2026Article
- How reliable are ROC cut-offs? Evidence from simulation and empirical analysis.BMC medical research methodology · 2026Article
- The Clinical Significance and Prognostic Value of Inflammatory Hematological Indices in Young Patients with Coronary Artery Disease.Journal of inflammation research · 2026Article
- Predictive value of systemic inflammatory response index for coronary artery disease and angiographic severity: a single-center retrospective study.Frontiers in cardiovascular medicine · 2026Article
- Association of Neutrophil-to-Lymphocyte Ratio With All-Cause and Cardiovascular Mortality Among Individuals With Depression: A Large-Scale Cohort Study.Brain and behavior · 2025Article
- A study on the correlation between the mean platelet volume to monocyte count ratio and long-term prognosis in patients with newly diagnosed coronary artery disease.Frontiers in cardiovascular medicine · 2025Article
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Abstract
backgroundThe objective of this research was to investigate the associations between inflammation markers and coronary artery disease (CAD), along with all-cause mortality and cardiovascular mortality.
methodsThis study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 2003 and 2018. The platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and systemic immune inflammation index (SII) were calculated based on blood test results. The diagnosis of CAD was obtained from self-reported cardiovascular health questionnaires. Participants' survival status was sourced from the National Death Index (NDI) of the National Center for Health Statistics (NCHS). Logistic and Cox regression models were employed to investigate the associations between PLR, NLR, MLR, and SII with CAD, all-cause mortality, and cardiovascular mortality.
resultsA total of 32,683 individuals from the 2003-2018 NHANES were involved. After adjusting for potential confounders, each 1-unit increase in log (NLR) and log (MLR) was associated with a 29% (95% CI: 1.15-1.46, P < 0.001) and 67% (95% CI: 1.40-1.99, P < 0.001) increase in the risk of CAD, respectively. Notably, when log (PLR) exceeded 4.93(PLR = 138.38) and log (SII) surpassed 6.11(SII = 450.34), the risk of CAD increased sharply (P < 0.001). Furthermore, individuals in the highest quartiles (Q4) of PLR, NLR, MLR, and SII had significantly higher risks of all-cause mortality (13%, 88%, 91%, and 42%, respectively) and cardiovascular mortality (48%, 194%, 139%, and 90%, respectively) compared to those in the lowest quartile (Q1), with all P-values <0.001. Moreover, MLR had the highest the area under the curve (AUC) value (AUC:0.642, 95% CI: 0.629-0.654), followed by NLR (AUC:0.600, 95% CI: 0.587-0.612) for distinguishing CAD.
conclusionIn this study, we found that PLR, NLR, MLR, and SII were associated with increased prevalence of CAD, as well as increased risks of all-cause and cardiovascular mortality. These inflammatory markers may serve as valuable clinical indicators for CAD, all-cause and cardiovascular mortality in the general population.
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