Evidence map›Paper›PMID 40632848›Full record

ArticleScience advances2025

Pressure-driven microinjection (PMI) of porous-coated balloon for ultrafast endoluminal drug delivery across biological barriers.

Honglin Qian, Jing Wang, Zhaohe Dai, Yirong Guo, Ke Liu, Xinyi Li, Meng Hu, Yan Yu, Jiarong Wang, Yuxian Lai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Honglin QianState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Xiaoshan District, Hangzhou, 311200, China.ORCID 0000-0001-6970-5568
Jing WangState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Xiaoshan District, Hangzhou, 311200, China.ORCID 0000-0002-7501-8702
Zhaohe DaiDepartment of Advanced Manufacturing and Robotics, Peking University, Haidian District, Beijing, 100871, China.ORCID 0000-0002-5205-089X
Yirong GuoMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.ORCID 0009-0006-2560-2931
Ke LiuState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Xiaoshan District, Hangzhou, 311200, China.ORCID 0000-0001-9081-6334
Xinyi LiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.
Meng HuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.
Yan YuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.
Jiarong WangMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.ORCID 0000-0001-9306-027X
Yuxian LaiMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.ORCID 0000-0001-9977-7706
Kefeng RenMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Xihu District, Hangzhou, 310058, China.ORCID 0000-0001-5456-984X
Jian JiState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital Zhejiang University School of Medicine, Xiaoshan District, Hangzhou, 311200, China.ORCID 0000-0001-9870-4038

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biological barriers play a crucial role in safeguarding the human body against pathogens yet pose severe challenges to efficient delivery of therapeutic drugs. Here, we introduce a pressure-driven microinjection (PMI) strategy for the robust and versatile delivery of functional species against biological barriers. With the benefits of elastic porous coating, this strategy enables the capillary suction of drug solutions, localized delivery, and ultrafast penetration through biological barriers by gentle pressure treatment. The penetration capacity is demonstrated by an unprecedented depth (~150 micrometers) of bovine serum albumin (66.4 kilodaltons) across aortic vessels under pressing for only 60 seconds. This spongy coating-based PMI technique can be integrated with medical balloon devices, offering endoluminal treatment within blood vessels, tracheas, and intestines. The in vivo evaluation indicated efficient trans-vascular delivery of 4-octyl itaconate, markedly reducing neointima hyperplasia. This PMI strategy provides a crucial insight for penetrative drug delivery across complex biological barriers.

Indexed as

Drug Delivery SystemsMicroinjectionsAnimalsCattleHumansPorosityPressureSerum Albumin, BovineSerum Albumin, Bovine

Identifiers

PMID40632848
PMCPMC12239961

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.