Evidence map›Paper›PMID 40633596›Full record

ReviewThe Journal of allergy and clinical immunology2025

Evolution of mast cell research associated with the Laboratory of Allergic Diseases, 1985-2022: Summary of the 2023 NIAID Symposium.

Hirsh D Komarow, Gunnar Nilsson, Yoshimichi Okayama, Yoseph Mekori, Ana Olivera, Peter Valent, Karin Hartmann, Knut Brockow, Glenn Cruse, Jonathan Lyons and 7 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of allergy and clinical immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hirsh D KomarowMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Md. Electronic address: komarowh@niaid.nih.gov.
Gunnar NilssonKarolinska Institute, Stockholm, Sweden.
Yoshimichi OkayamaNihon University School of Medicine, Tokyo, Misato Kenwa Hospital, Misato, the Showa University School of Medicine, Tokyo, and Gunma Paz University, Takasaki, Japan.
Yoseph MekoriMeir Medical Center, Kfar Saba, Tel Aviv University, Tel Aviv, Israel.
Ana OliveraMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Md.
Peter ValentDepartment of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria.
Karin HartmannDivision of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland.
Knut BrockowDepartment of Dermatology and Allergy Biederstein, Technical University of Munich, Munich, Germany.
Glenn CruseDepartment of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Jonathan LyonsDivision of Allergy & Immunology, Department of Medicine, University of California-San Diego, La Jolla, and the Veterans Affairs San Diego Healthcare System, La Jolla, Calif.
Amy D KlionHuman Eosinophil Section, Laboratory of Parasitic Diseases, NIAID, Bethesda, Md.
Cem AkinUniversity of Michigan Health, Ann Arbor, Mich.
Jason R GotlibDivision of Hematology, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, Calif.
Mariana CastellsHarvard Medical School, Boston, Mass.
Stephen J GalliStanford School of Medicine, Stanford, Calif.
Dean D MetcalfeMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Md.
Melody C CarterMast Cell Biology Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), Bethesda, Md.

Funding

The Pathogenesis, Diagnosis, And Treatment Of Systemic Mast Cell DisordersZIAAI000249 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KOMAROW, HIRSH D · 2009 to 2025
$16.5M
TPSAB1-derived tryptases promote myeloproliferation and anaphylaxisR00AI138586 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jonathan Lyons · 2024 to 2026
$2.3M
Intramural NIH HHS ZIA AI000249NIAID NIH HHS R00 AI138586
6 · The paper itself

Abstract

Present and former investigators of the Mast Cell Biology Section (MCBS) of the Laboratory of Allergic Diseases (LAD) and their colleagues organized a daylong symposium in October 2023 to honor the outstanding contributions of the MCBS headed by Dr Dean D. Metcalfe, who recently retired from his leadership role in this department. The symposium featured an overview of discoveries that advanced the scientific understanding of the human mast cell (MC) lineage and compartment over the preceding 3 decades. Insights into mechanisms and molecules contributing to MC expansion and function in health and disease, MC activation, and neoplastic MCs in mastocytosis were presented. The impact of these discoveries on the diagnosis and management of allergic diseases and MC disorders, as well as unmet needs in MC research, were reviewed. A summary of these discussions is provided.

Indexed as

HypersensitivityMast CellsAnimalsBiomedical ResearchCongresses as TopicHumansMastocytosisNational Institute of Allergy and Infectious Diseases (U.S.)United Statesdiagnostic criteriaKITMast cellsmastocytosistryptase

Identifiers

PMID40633596
PMCPMC12684638

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.