In one paragraphArticle in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Jianfeng Zhang *Department of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.ORCID http://orcid.org/0009-0005-1154-8092 Guilian Cao *Department of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.
Feng Li *Laboratory Medicine Center, The Sixth People's Hospital of Nantong (Affiliated Nantong Hospital of Shanghai University), Nantong, Jiangsu Province, China.
Siyu TangDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.
Chenxi WuDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.
Min JiangDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.
Jingxin YeDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.
Shaoqing JuDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China.ORCID http://orcid.org/0000-0001-7448-2020 Fei QianDepartment of Gastrointestinal Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China. qianfeint@163.com.ORCID http://orcid.org/0009-0002-1124-8565 Weifeng DingDepartment of Laboratory Medicine; Department of Gastroenterology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu Province, China. dwf@ntu.edu.cn.ORCID http://orcid.org/0000-0003-1713-3275 Funding
National Natural Science Foundation of China (National Science Foundation of China) 81974313, 82472364
6 · The paper itselfAbstract
Non-coding RNAs (ncRNAs) have important regulatory functions similar to traditional oncogenes or tumor suppressor genes. Our previous research found a novel pan-cancer downexpressed ncRNA, PANC754. However, its function and underlying mechanism remain obscure in colorectal cancer (CRC). In this study, in vitro and in vivo experiments were performed to determine the function of PANC754. Loss and gain of function experiments, molecular docking experiments, and bioinformatic analysis were utilized to visualize its pathway. Co-culture system was leveraged to explore its effect on synergetic immune checkpoint blockage against CRC. Through a series of studies, we found that overexpressed PANC754 significantly inhibited cell viability, migration, and metastasis and induced notable apoptosis in CRC. The mechanical research found that PANC754 was the nuclear-located and its expression was regulated by m
Indexed as
Colorectal NeoplasmsImmunotherapyMethyltransferasesRNA-Binding ProteinsAnimalsApoptosisCell Line, TumorGene Expression Regulation, NeoplasticHistonesHumansLysineMiceMice, Inbred BALB CMice, NudeRNA, UntranslatedSignal TransductionH3K4me1HistonesLysineMethyltransferasesRNA-Binding ProteinsRNA, Untranslated
Identifiers
PMID40634299
PMCPMC12241656
What Socratic holds
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LicenceCC BY
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