ArticleNature2025
Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders.FEBS letters · 2026Review
- CoQExperimental & molecular medicine · 2026Review
- Fmp30p is a mitochondrial phosphatidylinositol hydrolase that modulates CoQ biosynthesis.Nature communications · 2026Article
- Preclinical and first-in-human evidence of 4-hydroxybenzoic acid for mitochondrial COQ2 deficiency.Brain : a journal of neurology · 2026Article
- The Drp1-CoQ10-Coa6-ETC axis represents a therapeutic potential for working memory impairment caused by neuronal mitochondrial dysfunction.Translational neurodegeneration · 2026Article
- Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.International journal of molecular sciences · 2026Review
- A bioinorganic view on the potential chemical space of hydroxyphenylpyruvate dioxygenase-like (HPDL) enzymes.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Loss of function variants in HPDL impair human cortical development via alterations of mitochondrial function.Cell death & disease · 2026Article
- Mitochondrial encephalomyopathy caused by a novel ACAD9 mutation: a case report.Frontiers in human neuroscience · 2026Article
- Blood-Brain Barrier and Neuronal Model Systems for Studying CoQAntioxidants (Basel, Switzerland) · 2025Review
- Children with Genetically Confirmed Hereditary Spastic Paraplegia: A Single-Center Experience.Children (Basel, Switzerland) · 2025Article
- Exploring the protective effects of coenzyme Q10 on female fertility.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Guangbin Shi *Department of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0009-0009-1679-4355
Claire Miller *Department of Neurology, The Marlene and Paolo Fresco Institute for Parkinsons and Movement Disorders, NYU Grossman School of Medicine, New York, NY, USA.
Sota KunoDepartment of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-6431-4437
Alejandro G Rey HipolitoDepartment of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Salsabiel El NagarDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Giulietta M RiboldiDepartment of Neurology, The Marlene and Paolo Fresco Institute for Parkinsons and Movement Disorders, NYU Grossman School of Medicine, New York, NY, USA.
Megan KornLaura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.ORCID 0000-0002-9280-2013
Wyatt C TranLaura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.ORCID 0009-0002-6162-6261
Zixuan WangDepartment of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.
Lia FicaroMetabolomics Core Research Laboratory, NYU Grossman School of Medicine, New York, NY, USA.
Tao LinDepartment of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.ORCID 0000-0002-6441-067X
Quentin SpillierDepartment of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.
Begoña Gamallo-LanaDepartment of Neuroscience and Physiology Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
Drew R JonesDepartment of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-8732-9818
Matija SnuderlDepartment of Pathology, NYU Grossman School of Medicine, New York, NY, USA.
Soomin C SongIonLab, Department of Pathology, NYU Langone Health, New York, NY, USA.
Adam C MarDepartment of Neuroscience and Physiology Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, USA.
Alexandra L JoynerDevelopmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-7090-9605
Roy V SillitoeDepartment of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.
Robert S BanhLaura and Isaac Perlmutter Cancer Center, NYU Langone Health, New York, NY, USA.ORCID 0000-0003-1959-4622
Michael E PacoldDepartment of Radiation Oncology, NYU Grossman School of Medicine, New York, NY, USA. michael.pacold@nyulangone.org.ORCID 0000-0003-3688-2378
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Michael Jason de la Cruz · 1985 to 2026
$347.4MProject-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Nancy Chan · 1985 to 2026
$83.1MU19 Supplement 2023-FroemkeU19NS107616 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KENWAY LOUIE · 2018 to 2026
$36.4MPreclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9MSteps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, SAMACO, RODNEY C · 2014 to 2019
$7.8MEngrailed genes and cerebellum morphology, spatial gene expression and circuitryR37MH085726 · NIMH · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2014 to 2023
$6.7MCRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6MSignaling Pathways that Regulate Scaling and Regeneration of the CerebellumR01NS092096 · NINDS · SLOAN-KETTERING INST CAN RESEARCH · PI JOYNER, ALEXANDRA L. · 2015 to 2024
$4.8MTraining in Cellular, Molecular and Biomedical Studies (CMBS)T32GM145766 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler, RONALD K. LIEM · 2022 to 2026
$4.1MCellular Adaptations to Nutrient-Limited Metabolic MicroenvironmentsR35GM147119 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Michael Edward Pacold · 2022 to 2026
$2.1MCerebellar Deep Brain StimulationR01NS119301 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2020 to 2024
$2.0MNCATS NIH HHS UL1 TR001445NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA016087NCI NIH HHS R37 CA289040NIAID NIH HHS R01 AI097302NICHD NIH HHS P50 HD103555NICHD NIH HHS U54 HD083092NIGMS NIH HHS R35 GM147119NIGMS NIH HHS T32 GM145766NIMH NIH HHS R37 MH085726NINDS NIH HHS R01 NS092096NINDS NIH HHS R01 NS119301NINDS NIH HHS R01 NS127435NINDS NIH HHS U19 NS107616
Abstract
Decreased brain levels of coenzyme Q
Indexed as
Mitochondrial EncephalomyopathiesUbiquinoneAnimalsAtaxiaBrainDisease Models, AnimalFemaleHumansMaleMiceMitochondrial DiseasesMuscle WeaknessParabens4-hydroxybenzoic acidcoenzyme Q10ParabensUbiquinoneubiquinone 9
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.