Evidence map›Paper›PMID 40634669›Full record

ArticleThe EMBO journal2025

FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons.

Daisuke Kohno, Reika Kawabata-Iwakawa, Sotaro Ichinose, Shigetomo Suyama, Kazuto Ohashi, Winda Ariyani, Tetsushi Sadakata, Hiromi Yokota-Hashimoto, Ryosuke Kobayashi, Takuro Horii and 12 more

Abstract read
In one paragraph

Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Daisuke KohnoMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan. daisuke.kohno@gunma-u.ac.jp.ORCID http://orcid.org/0009-0001-1073-2745
Reika Kawabata-IwakawaDivision of Integrated Oncology Research, Gunma University Initiative for Advanced Research (GIAR), Maebashi, Japan.
Sotaro IchinoseDepartment of Anatomy, Gunma University Graduate School of Medicine, Maebashi, Japan.ORCID http://orcid.org/0000-0002-1470-2957
Shigetomo SuyamaDepartment of Physiology, Keio University School of Medicine, Tokyo, Japan.
Kazuto OhashiInstitute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.ORCID http://orcid.org/0000-0002-6517-1156
Winda AriyaniMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.ORCID http://orcid.org/0000-0003-4813-6604
Tetsushi SadakataEducation and Research Support Center, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hiromi Yokota-HashimotoMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Ryosuke KobayashiLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Takuro HoriiLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Vina Yanti SusantiMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.ORCID http://orcid.org/0000-0003-1207-2725
Ayumu KonnoDepartment of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Japan.ORCID http://orcid.org/0000-0001-9382-396X
Haruka TsuneokaMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Chiharu YoshikawaMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Sho MatsuiDivision of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
Akihiro HaradaDepartment of Cell Biology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.ORCID http://orcid.org/0000-0002-2484-9784
Toshihiko YadaDivision of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Izuho HatadaLaboratory of Genome Science, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.
Hirokazu HiraiDepartment of Neurophysiology & Neural Repair, Gunma University Graduate School of Medicine, Maebashi, Japan.
Masahiko NishiyamaGunma University, Maebashi, Japan.ORCID http://orcid.org/0000-0001-9731-7183
Tsutomu SasakiDivision of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-8041-1915
Tadahiro KitamuraMetabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan.

Funding

BINDS JP21am0101120BINDS JP24wm0625103MEXT | Japan Society for the Promotion of Science (JSPS) 17K08566MEXT | Japan Society for the Promotion of Science (JSPS) 21H03349MEXT | Japan Society for the Promotion of Science (JSPS) 23K21617MEXT | Japan Society for the Promotion of Science (JSPS) 25870666MEXT | Japan Society for the Promotion of Science (JSPS) 25K03043MEXT | Japan Society for the Promotion of Science (JSPS) JPMXS0420600120MEXT | Japan Society for the Promotion of Science (JSPS) New Paradigms - Establishing Centres for Fostering Medical Researchers of the Future programsMEXT | Japan Society for the Promotion of Science (JSPS) the Fostering Health Professionals for Changing Needs of CancerMEXT | Japan Society for the Promotion of Science (JSPS) the Promotion Plan for the Platform of Human Resource Development for CancerWellcome Trust
6 · The paper itself

Abstract

N

Indexed as

Agouti-Related ProteinAlpha-Ketoglutarate-Dependent Dioxygenase FTOAlternative SplicingAxonsKinesinsNeuronsWeight GainAdenosineAnimalsHypothalamusMaleMiceMice, Inbred C57BLMice, KnockoutAdenosineAgouti-Related ProteinAgrp protein, mouseAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseKinesinsN-methyladenosineAgRPAlternative SplicingFTOKIF1AObesity

Identifiers

PMID40634669
PMCPMC12436618

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.