ArticleDiabetes, obesity & metabolism2025
Cardiovascular autonomic dysfunction precedes cardiovascular disease and all-cause mortality: 11-year follow-up in the ADDITION-PRO study.
Article in Diabetes, obesity & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Atrial cardiomyopathy as a multidomain disease: longitudinal evidence for autonomic remodelling.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Role of Exercise in Modulating the Brain-Heart Axis in Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- From Beat to Risk: How Heart Rate Variability Predicts Arrhythmias in Type 2 Diabetes.Life (Basel, Switzerland) · 2026Review
- Cardiovascular autonomic dysfunction is linked with arterial stiffness across glucose metabolism: the Maastricht study.BMJ open diabetes research & care · 2026Article
- Effect of 12 Weeks Yoga Therapy on Heart Rate Variability and Baroreflex Sensitivity in Female Hypothyroid Patients: A Randomised Control Trial.Annals of neurosciences · 2025Article
- Cardiovascular autonomic dysfunction precedes cardiovascular disease and all-cause mortality: 11-year follow-up in the ADDITION-PRO study.Diabetes, obesity & metabolism · 2025Article
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9 authors.
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Abstract
aimWe aim to determine the impact of multiday heart rate variability (HRV) on the risk of major adverse cardiovascular events (MACE), heart failure and mortality in people at high risk of diabetes. MATERIALS AND
methodsMultiday HRV and mean heart rate (mHR) were measured in 1627 participants from the ADDITION-PRO study between 2009 and 2011. As measurement for HRV, we calculated a proxy for standard deviation of normal heartbeat (SDNN) both weekly, daily and hourly. Data on MACE and all-cause mortality were obtained from Danish patient registers until 2021. We fitted Poisson regression to determine incidence rate ratios (IRR) for MACE (myocardial infarction, stroke and cardiovascular death), heart failure and all-cause mortality.
resultsMean (SD) age was 66 years (7), and 47% were women. The population had a mean (SD) multiday SDNN of 139.0 (32.3) milliseconds. Multiday HRV index SDNN showed an IRR of 0.82 (CI: 0.69; 0.97), 0.76 (CI: 0.58; 0.99) and 0.79 (CI: 0.66; 0.94) per SD for MACE, heart failure and all-cause mortality, respectively. SDNN measurements taken from 6:00 AM to 7:00 AM showed the strongest association with the risk of MACE. Lower SDNN was associated with all-cause mortality across all hours of the day. Adjustment for physical acceleration and heart rate did not materially change the magnitude of these associations.
conclusionCardiovascular autonomic dysfunction, measured by multiday HRV, is linked with MACE, heart failure and all-cause mortality. Certain time frames of the day for HRV and heart rate under free-living conditions showed a higher risk of cardiovascular disease.
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