Evidence map›Paper›PMID 40635413›Full record

SynthesisJournal of cardiovascular electrophysiology2025

Pentaspline Pulsed Field Ablation Versus High-Power Short-Duration/Very High-Power Short-Duration Radiofrequency Ablation in Atrial Fibrillation: A Meta-Analysis.

Marco Valerio Mariani, Andrea Matteucci, Nicola Pierucci, Marta Palombi, Paolo Compagnucci, Raffaele Bruti, Pietro Cipollone, Sara Vinciullo, Sara Trivigno, Agostino Piro and 9 more

Abstract readMeta-Analysis
In one paragraph

Synthesis in Journal of cardiovascular electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Article
  8. Review
  9. Clinical outcomes after catheter ablation for atrial fibrillation in elderly patients: a meta-analysis with time-to-event data reconstruction.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Efficacy, safety, and procedural outcomes of pulsed field ablation for cavotricuspid isthmus-dependent atrial flutter: a systematic review and single-arm meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026
    Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marco Valerio MarianiDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.ORCID 0000-0002-9480-1209
Andrea MatteucciClinical and Rehabilitation Cardiology Division, San Filippo Neri Hospital, Rome, Italy.ORCID 0000-0002-8831-6178
Nicola PierucciDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.ORCID 0000-0002-5985-4081
Marta PalombiDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.ORCID 0009-0005-5092-3115
Paolo CompagnucciCardiology and Arrhythmology Clinic, University Hospital "Azienda Ospedaliero-Universitaria delle Marche", Ancona, Italy.ORCID 0000-0003-1924-6548
Raffaele BrutiDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.
Pietro CipolloneDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.
Sara VinciulloDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.
Sara TrivignoDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.
Agostino PiroDepartment of Cardiovascular, Respiratory, Nephrological, Aenesthesiological and Geriatric Sciences "Sapienza" University of Rome, Rome, Italy.ORCID 0000-0002-5995-4963
Vincenzo Mirco La FaziaDepatrment of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy.
Wael SaadeDepartment of Internal Clinical, Aenesthesiological and Cardiovascular Sciences "Sapienza" University of Rome, Rome, Italy.
Cristina ChimentiDepartment of Internal Clinical, Aenesthesiological and Cardiovascular Sciences "Sapienza" University of Rome, Rome, Italy.
Giovanni Battista ForleoCardiology Unit, Luigi Sacco University Hospital, Milan, Italy.
Antonio Dello RussoCardiology and Arrhythmology Clinic, University Hospital "Azienda Ospedaliero-Universitaria delle Marche", Ancona, Italy.
Claudio PandoziClinical and Rehabilitation Cardiology Division, San Filippo Neri Hospital, Rome, Italy.ORCID 0000-0002-5476-4124
Andrea NataleDepatrment of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy.ORCID 0000-0002-5487-0728
Carmine Dario VizzaDepartment of Internal Clinical, Aenesthesiological and Cardiovascular Sciences "Sapienza" University of Rome, Rome, Italy.
Carlo LavalleDepartment of Internal Clinical, Aenesthesiological and Cardiovascular Sciences "Sapienza" University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulsed field energy has been proposed as alternative to radiofrequency energy in atrial fibrillation (AF) ablation.

objectiveTo compare data from studies assessing AF ablation with pulsed field ablation (PFA) versus high-power short-duration (HPSD) or very HPSD (vHPSD) radiofrequency ablation (RFA) in terms of AF recurrence, procedure-related complications, fluoroscopy and procedure times.

methodsA search of online scientific libraries (from inception to October 1, 2024) was performed. Six studies were considered eligible for the meta-analysis totaling 1190 patients of whom 568 receiving PFA and 622 receiving HPHD/vHPSD RFA.

resultsIn patients with paroxysmal AF (PAF), a nonsignificant reduction of AF recurrence was related to PFA as compared to HPSD/vHPSD RFA (OR 0.74 [0.50; 1.11], p = 0.14, I

conclusionPFA in AF patients is associated with similar efficacy and safety profiles as compared to HPSD/vHPSD RFA.

Indexed as

Atrial FibrillationCatheter AblationAction PotentialsAgedFemaleHeart RateHumansMaleMiddle AgedOperative TimeRecurrenceRisk AssessmentRisk FactorsTime FactorsTreatment Outcomeatrial fibrillationhigh‐power short‐duration ablationpulmonary vein isolationpulsed field ablationradiofrequency ablation

Identifiers

PMID40635413
PMCPMC12420869

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.