The impact of sedation and analgesia scores on prognosis in critically ill sepsis patients with sepsis-associated encephalopathy: a retrospective analysis.

Background: Sepsis is a critical condition resulting from a poor immune response to infection, often leading to complications like sepsis-associated encephalopathy (SAE). Research suggests a link between sedation and analgesia use and SAE development in intensive care unit (ICU) patients, but study inconsistencies limit definitive conclusions. This study aims to explore the relationship between sedation and analgesia scores and the occurrence of SAE in the ICU, as well as their impact on clinical effectiveness and patient prognosis. Methods: Between January 1, 2021, and August 30, 2022, a retrospective analysis of 356 sepsis cases was conducted in the Emergency ICU of the Affiliated Hospital of Guizhou Medical University. After excluding 102 patients, 219 were included and divided into SAE and non-SAE groups for analysis. Results: The SAE group demonstrated higher age, Sequential Organ Failure Assessment (SOFA) scores, and APACHE II scores, alongside longer ICU durations and lower Glasgow Coma Scale (GCS) scores ( Conclusion: The study demonstrated that patients with SAE exhibit physiological disturbances, including elevated inflammatory markers (IL-6 and LDH), impaired oxygenation, and acid-base imbalances, which may contribute to more severe clinical courses. Additionally, RASS and BPS scores were found to be reliable indicators of patient prognosis in sepsis. These findings may guide clinical practice in managing patients with SAE.