Evidence map›Paper›PMID 40635717›Full record

ReviewInternational journal of nanomedicine2025

Materials, Syntheses and Biomedical Applications of Nano-Quercetin Formulations: A Comprehensive Literature Review.

Han Wang, Wenli Di, Xibao Gao, Yuanyuan Guo, Tian Tang, Xue Bai, Hongqian Cao

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han Wang *Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Wenli Di *Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Xibao Gao *Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Yuanyuan Guo *Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Tian TangDepartment of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Xue BaiDepartment of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.
Hongqian CaoDepartment of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quercetin (Qu), a naturally occurring flavonoid with potent antioxidant, anti-inflammatory, and anticancer properties, faces clinical limitations due to poor solubility, low stability, and suboptimal bioavailability. This review comprehensively explores nano-quercetin (nano-Qu) formulations as a transformative solution, focusing on material design, synthesis strategies, and biomedical applications. A comprehensive review of diverse nanocarriers, including lipid-based, inorganic, polymeric, and composite nanoparticles, is presented to systematically evaluate their potential in improving solubility, stability, and targeted drug delivery of Qu. Advanced synthesis techniques such as chemical conjugation, self-assembly, and physical encapsulation are evaluated for optimizing drug loading and controlled release. Preclinical studies highlight nano-Qu's efficacy in cancer therapy, inflammatory disorders, metabolic diseases, and tissue regeneration, attributed to improved pharmacokinetics and target-specific mechanisms. Despite promising advancements, challenges in biocompatibility, long-term toxicity, and scalable production require further investigation. This work underscores the potential of nanotechnology to unlock Qu's therapeutic versatility.

Indexed as

NanoparticlesQuercetinAnimalsAnti-Inflammatory AgentsAntioxidantsDrug CarriersDrug Delivery SystemsHumansSolubilityAnti-Inflammatory AgentsAntioxidantsDrug CarriersQuercetinbiomedical applicationsmaterialsnanotechnologyquercetinsynthesis methods

Identifiers

PMID40635717
PMCPMC12239925

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.