ReviewFrontiers in pharmacology2025
Efficacy of different dosages of common uric acid-lowering medications in gout patients: a network meta-analysis of randomized control trials.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Rapid and regular dose escalation in urate lowering therapy: a pragmatic clinical trial.Clinical rheumatology · 2026Trial
- Febuxostat alleviates testicular dysfunction induced by cyclophosphamide in rats via modulation of pyroptosis and mTOR autophagy axis.Scientific reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Urate lowering therapy (ULT) is extensively utilized for managing patients with gout. This study aims to compare the efficacy of different ULTs on serum uric acid (SUC) levels, gout flares, and adverse events (AEs) in gout patients. Methods: Studies comparing the efficacy of febuxostat, allopurinol, benzbromarone, and topixostat with placebo were searched up to March 2024. Stata 15.1 and R software 4.2.3 were employed to rank the efficacy of each ULT. Results: This study included 30 studies, involving 20,040 patients. All ULTs resulted in notably lower SUC levels compared to placebo/no ULT. Febuxostat 120 mg markedly reduced SUC levels compared to allopurinol and benzbromarone 25 mg (mean difference = 2.16, 95% confidence interval [0.27, 4.06], P < 0.05). Allopurinol 200/300 mg was the best choice to reduce gout flares. In terms of AEs, the allopurinol group (300 mg) had the lowest incidence of cardiovascular and renal abnormalities. Moreover, the incidence of AEs was observed to rise with increasing doses. Future well-designed randomized control trials are required to further confirm these findings. Conclusion: The study results indicate that febuxostat is the most effective ULT drug to treat gout. It can effectively help gout patients reduce SUC levels. Researchers should pay attention to the safety of drug doses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.