ReviewFrontiers in immunology2025
Pyroptosis as a therapeutic target in preeclampsia: current research and future directions.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The Immunopathology of Preeclampsia.Biomedicines · 2026Review
- Single-cell and spatial transcriptomics identify SPP1 + trophoblast necroptosis as a potential contributor to late-onset preeclampsia via SPP1-CD44-mediated interaction with macrophages.Journal of translational medicine · 2026Article
- Inflammasome biology in preeclampsia: from Bnip3-mitophagy to Nlrp1-driven placental injury - a systematic review and translational roadmap.Journal of perinatal medicine · 2026Review
- SETD7-mediated epigenetic regulation of LncRNA XIST promotes trophoblast pyroptosis: a study in preeclampsia mouse and cell models.Biology direct · 2026Article
- Cell-Based and Cell-Free Non-Invasive Prenatal Analysis of Preeclampsia: An Updated Review of Liquid Biopsy.Biomedicines · 2026Review
- Integrative Transcriptomic and Network Pharmacology Analysis Suggests Potential Mechanisms of Propofol in Early-Onset Preeclampsia.International journal of women's health · 2026Article
- Decoding the molecular mechanisms of pyroptosis and its therapeutic development prospects.Frontiers in cell and developmental biology · 2026Review
- Decoding m6A: a new frontier in maternal-foetal immunology.Frontiers in immunology · 2026Review
- Direct and indirect evidence for pyroptosis and immune dysregulation in IVF/ICSI-ET-related early pregnancy loss.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Preeclampsia (PE) is a severe pregnancy-specific disorder characterized by new-onset hypertension and proteinuria after the 20th week of gestation, posing significant threats to maternal and fetal health. Globally, approximately 4 million women are diagnosed with PE annually, resulting in over 70,000 maternal deaths and 500,000 infant deaths. The exact pathogenesis of PE remains unclear and is associated with multiple factors, including obesity, diabetes, and chronic kidney disease. Pyroptosis, a newly discovered form of programmed cell death, is characterized by plasma membrane rupture and the release of numerous inflammatory mediators. Studies have shown that trophoblast pyroptosis is closely related to PE, potentially hindering trophoblast invasion, causing abnormal remodeling of uterine spiral arteries, and inducing systemic inflammatory responses. This review summarizes the latest research progress on the correlation between trophoblast pyroptosis and the pathogenesis of PE. It explores the regulatory roles of NLRP3 Inflammasome,oxidative stress, T helper type 1 (Th1)/T helper type 2 (Th2) cell imbalance, microRNAs and other factors in trophoblast pyroptosis, providing potential targets for the development of early diagnostic biomarkers and therapeutic strategies for PE.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.