Evidence map›Paper›PMID 40636286›Full record

ReviewMedComm2025

Current Bioinformatics Tools in Precision Oncology.

Tesfaye Wolde, Vipul Bhardwaj, Vijay Pandey

Abstract readReview
In one paragraph

Review in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tesfaye WoldeInstitute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China.
Vipul BhardwajTsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China.ORCID https://orcid.org/0000-0001-5509-8840
Vijay PandeyInstitute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School Tsinghua University Shenzhen China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrating bioinformatics tools has profoundly transformed precision oncology by identifying essential molecular targets for personalized treatment. The rapid development of high-throughput sequencing and multiomics technologies creates complex datasets that require robust computational methods to extract meaningful insights. Nonetheless, the clinical application of multiomics data continues to pose significant challenges. This review explores advanced bioinformatics tools utilized within multiomics, emphasizing their pivotal role in discovering cancer biomarkers. Cloud-based platforms, such as Galaxy and DNAnexus, facilitate streamlined data processing, while single-cell analysis software, including Seurat, identifies rare cellular subpopulations. Further integration of artificial intelligence with machine learning approaches improves predictive modeling and diagnostic accuracy. Spatial omics technologies correlate molecular signatures within tumor microenvironments, guiding treatment strategies. Bioinformatics integrates these technologies to establish a new standard in precision oncology, thereby enhancing therapy efficacy. Collaborative initiatives between The Cancer Genome Atlas and cBioPortal expedite advancements through the sharing open data and implementing standardized methodologies. Advancing multiomics integration techniques alongside improved computational capabilities is essential for discovering new biomarkers and refining precision medicine strategies. Future efforts should focus on merging multiomics techniques with innovative computational methods to drive novel biomarker discovery and improve precision medicine applications.

Indexed as

bioinformaticsbiomarkersmultiomiconcotherapeuticsprecision oncology

Identifiers

PMID40636286
PMCPMC12238682

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.