Evidence map›Paper›PMID 40636673›Full record

ArticleFrontiers in cell and developmental biology2025

Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte

Chiara Camerano Spelta Rapini, Alessia Peserico, Chiara Di Berardino, Giulia Capacchietti, Camila Rojo-Fleming, Andrada-Ioana Damian-Buda, Irem Unalan, Aldo Roberto Boccaccini, Valentina Grossi, Mauro Mattioli and 1 more

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In one paragraph

Article in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chiara Camerano Spelta Rapini *Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Alessia Peserico *Department of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Chiara Di BerardinoDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Giulia CapacchiettiDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Camila Rojo-FlemingDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Andrada-Ioana Damian-BudaDepartment of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany.
Irem UnalanDepartment of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany.
Aldo Roberto BoccacciniDepartment of Materials Science and Engineering, Institute of Biomaterials, University of Erlangen-Nuremberg, Erlangen, Germany.
Valentina GrossiMedical Genetics, National Institute of Gastroenterology, IRCCS "Saverio de Bellis" Research Hospital, Castellana Grotte (Ba), Italy.
Mauro MattioliDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.
Barbara BarboniDepartment of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Teramo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: SMYD3 is a histone methyltransferase known for its dual role in modifying both histone and non-histone proteins. Despite its established involvement in somatic cell function and oncogenesis, its role in mammalian oogenesis and early embryonic development remains unclear. This study aimed to elucidate the function of SMYD3 in regulating oocyte meiotic progression and developmental competence using sheep as a mono-ovulatory model. Results: Utilizing a 3D follicle-enclosed Conclusion: SMYD3 is identified as a key modulator of oocyte maturation, orchestrating meiotic progression through CDC25A regulation and interacting with hCG-driven somatic signaling. These findings highlight SMYD3 as a critical determinant of late oogenesis and a potential target for enhancing oocyte competence in assisted reproductive technologies.

Indexed as

cumulus-oocyte metabolic couplingfollicle-enclosed oocyte in vitro maturation (FEO-IVM)hCG-dependent signaling pathwaysovine oocyte competenceSMYD3

Identifiers

PMID40636673
PMCPMC12238014

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.