Evidence map›Paper›PMID 40636787›Full record

ReviewiLIVER2025

Emerging role of natural bioactive compounds in navigating the future of liver disease.

Neha Chaudhary, Muhammad Arif, Sheeba Shafi, Shom Prakash Kushwaha, Pushpendra Soni

Abstract readReview
In one paragraph

Review in iLIVER, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Nano-Enhanced Diets: Advancing Metabolic Dysfunction-Related Steatotic Liver Disease (MASLD) - A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Neha ChaudharyFaculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, India.
Muhammad ArifFaculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, India.
Sheeba ShafiDepartment of Nursing, College of Applied Medical Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Shom Prakash KushwahaFaculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, India.
Pushpendra SoniFaculty of Pharmacy, Integral University, Dasauli, Kursi Road, Lucknow 226026, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver diseases, including liver inflammation, fatty liver disease, cirrhosis, and hepatocellular carcinoma, represent significant global health challenges. Traditional treatments often emphasize symptom management, leading to increased interest in natural bioactive compounds for their potential therapeutic benefits. This review examines the role of natural bioactive compounds in managing hepatic disorders, with a particular focus on their mechanisms of action and supporting clinical evidence. Compounds such as curcumin, silymarin, resveratrol, triterpenoids, apigenin, and delphinidin derivatives have demonstrated promising hepatoprotective effects in preclinical studies, largely due to their anti-inflammatory, antioxidant, and anti-fibrotic properties. Nevertheless, further research is necessary to determine optimal dosing, safety profiles, and long-term effects. Understanding the mechanisms of action and therapeutic potential of these bioactive compounds may provide critical insights into their role in the treatment of hepatic diseases.

Indexed as

Alcohol-associated hepatic diseaseAutoimmune hepatitisHepatoprotectiveMedicine-induced hepatic injuryNonalcoholic fatty hepatic diseaseResveratrolViral hepatitis

Identifiers

PMID40636787
PMCPMC12212691

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.