Evidence map›Paper›PMID 40636813›Full record

ArticleBrain communications2025

Network changes associated with right anterior temporal lobe atrophy: insight into unique symptoms.

Hulya Ulugut, Maria Luisa Mandelli, Anna Gilioli, Zoe Ezzes, Janhavi Pillai, David Baquirin, Amie Wallman-Jones, Amanda Gerenza, Eleanor R Palser, Aaron Scheffler and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Hulya Ulugut *Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Maria Luisa Mandelli *Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Anna GilioliMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Zoe EzzesMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Janhavi PillaiMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
David BaquirinMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Amie Wallman-JonesMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Amanda GerenzaMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Eleanor R PalserMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Aaron SchefflerDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA 94158, USA.
Giovanni BattistellaDepartment of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear and Harvard Medical School, Boston, MA 02114, USA.
Yann CobigoMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Howard J RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Zachary A MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.ORCID https://orcid.org/0000-0002-5991-3053
Kyan YounesDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94304, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Joel KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Virginia E SturmMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94158, USA.

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Attention and Semantic Evaluation as Predictors of Empathy in Healthy Aging and Frontotemporal DementiaRF1AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2019 to 2019
$4.0M
Measuring Altered Social Behavior in Neurodegenerative DiseaseR01AG029577 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RANKIN, KATHERINE P · 2008 to 2018
$3.6M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Neuroimaging and genetics of the glymphatic system in Alzheimer's diseaseK23AG090733 · NIA · STANFORD UNIVERSITY · PI Kyan Younes · 2025 to 2026
$332k
NIA NIH HHS K23 AG090733NIA NIH HHS P01 AG019724NIA NIH HHS R01 AG029577NIA NIH HHS R01 AG052496NIA NIH HHS RF1 AG029577NIDCD NIH HHS K24 DC015544NINDS NIH HHS RF1 NS050915
6 · The paper itself

Abstract

Semantic behavioural variant (also referred to as right temporal) frontotemporal dementia is a newly described syndrome associated with predominant right anterior temporal lobe atrophy and a distinctive combination of behavioural and semantic changes. It is considered the right-sided counterpart of semantic variant primary progressive aphasia, with which it has overlapping neuropathological and cognitive mechanisms. Although more is known about how brain network alterations relate to both losses (e.g. word comprehension deficits) and increases (e.g. hyper-fluency) in cognitive and behavioural processes in the left-sided semantic progressive aphasia, less is known about these phenomena in the right-sided semantic behavioural variant. In this study, we investigated functional connectivity within the right counterparts of established ventral and dorsal cortical speech and language networks and their relationship to specific clinical manifestations in individuals with the semantic behavioural variant. We hypothesized that socioemotional-semantic deficits would be associated with reduced connectivity in the right ventral semantic network, while heightened behavioural manifestations, such as hyper-focus on specific interests (also referred to as rigidity), would be associated with increased connectivity in the right dorsal network. Using seed-based intrinsic connectivity analyses of functional MRI data and cognitive scores from 22 individuals with semantic behavioural variant frontotemporal dementia and 48 cognitively normal individuals, we measured intrinsic connectivity strength in networks anchored in the right anterior middle temporal gyrus (ventral network) and in the right opercular inferior frontal gyrus (dorsal network). Functional connectivity values were then correlated with cognitive and behavioural measurements, controlling for global atrophy. Compared to the control group, individuals with semantic behavioural variant exhibited reduced connectivity in the right ventral network (

Indexed as

anterior temporal lobefrontotemporal dementiafunctional connectivitymental rigiditysocial semantics

Identifiers

PMID40636813
PMCPMC12238713

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.