Evidence map›Paper›PMID 40636957›Full record

ArticleCirculation research2025

Arterial Myocyte Pannexin 1 Channel Controls Vascular Reactivity in Diabetic Hyperglycemia.

Junyoung Hong, Miguel Martín-Aragón Baudel, Sayeman Islam Niloy, Jade Taylor, Yaseen Mohabbat, Yumna Moustafa, Eric Pereira Da Silva, Brooke L O'Donnell, Zhenduo Zhu, Nuria Daghbouche-Rubio and 7 more

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Article in Circulation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Uncovering a Sex-Specific cAMP Landscape in Vascular Smooth Muscle.bioRxiv : the preprint server for biology · 2026
    Article
  2. CaThe Journal of physiology · 2026
    Article
  3. Article
  4. Article
  5. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Junyoung Hong *Department of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0002-7261-2204
Miguel Martín-Aragón Baudel *Department of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0001-9399-4013
Sayeman Islam NiloyDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Jade TaylorDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0001-7158-2712
Yaseen MohabbatDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Yumna MoustafaDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Eric Pereira Da SilvaDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0003-1362-1298
Brooke L O'DonnellRobert M Berne Cardiovascular Research Center and Department of Molecular Physiology and Biophysics, University of Virginia, Charlottesville, VA (B.L.O., B.E.I.).ORCID 0000-0001-6025-8300
Zhenduo ZhuDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Nuria Daghbouche-RubioDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Gopyreddy R ReddyDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).
Kent C SasseSasse Surgical Associates, Reno, NV (K.C.S.).
Sean M WardDepartment of Physiology and Cell Biology, University of Nevada Reno, Reno, NV (S.M.W.).
Yang K XiangDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0003-1786-9143
Brant E IsaksonRobert M Berne Cardiovascular Research Center and Department of Molecular Physiology and Biophysics, University of Virginia, Charlottesville, VA (B.L.O., B.E.I.).ORCID 0000-0002-7692-6294
Madeline Nieves-CintrónDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0003-1935-8400
Manuel F NavedoDepartment of Pharmacology, University of California Davis, Davis, CA (J.H., M.M.-A.B., S.I.N., J.T., Y. Mohabbat, Y. Moustafa, E.P.D.S., Z.Z., N.D.-R., G.R.R., Y.K.X., M.N.-C., M.F.N.).ORCID 0000-0001-6864-6594

Funding

Role of Pannexins in Vascular Smooth Muscle CellsP01HL120840 · NHLBI · UNIVERSITY OF VIRGINIA · PI BAYLISS, DOUGLAS A. · 2014 to 2023
$24.0M
Purinergic Regulation of Veinous Endothelial PermeabilityR01HL137112 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson, MICHAEL H. KOVAL · 2018 to 2026
$4.7M
Coupling of Vascular Cav1.2 Channels In Health & DiseaseR01HL121059 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2015 to 2024
$4.5M
Cerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7M
cAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6M
Regulation of a cardiac b1AR/SERCA2 complex in heart failureR01HL162825 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG KEVIN · 2022 to 2025
$2.5M
Mechanisms of VSM dysfunction in diabetes and HFpEFR01HL171014 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Manuel F Navedo, Madeline Nieves-Cintron · 2024 to 2026
$2.0M
Panx1-PIEZO1 Interactions Regulate Renin ReleaseR01HL171997 · NHLBI · UNIVERSITY OF VIRGINIA · PI Brant E Isakson · 2024 to 2026
$2.0M
Molecular Regulation of cardiac adrenergic signalingR01HL147263 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI XIANG, YANG K · 2019 to 2022
$1.7M
BLRD VA I01 BX005100BLRD VA IK6 BX005753NHLBI NIH HHS P01 HL120840NHLBI NIH HHS R01 HL121059NHLBI NIH HHS R01 HL137112NHLBI NIH HHS R01 HL147263NHLBI NIH HHS R01 HL149127NHLBI NIH HHS R01 HL161872NHLBI NIH HHS R01 HL162825NHLBI NIH HHS R01 HL171014NHLBI NIH HHS R01 HL171997
6 · The paper itself

Abstract

backgroundDiabetic hyperglycemia promotes vasoconstriction by activating an ATP-dependent P2Y

methodsMultidisciplinary approach using extracellular ATP and cAMP biosensors, patch-clamp electrophysiology, super-resolution nanoscopy, proximity ligation assay, pressure myography, and laser speckle imaging to test premises in arterial myocytes and vessels from wild-type and genetically modified mice, including an inducible smooth muscle-specific Panx1 knockout and a global AKAP5 knockout.

resultsWe found that elevating extracellular glucose (eg, high glucose, hyperglycemia) triggered an increase in extracellular ATP levels, and this was reduced in the presence of the Panx1 inhibitor spironolactone, in inducible smooth muscle-specific Panx1 knockout cells, and by inhibiting glucose metabolism. Panx1 was found in complex with P2Y

conclusionsThese results suggest a key role for Panx1 in controlling ATP signaling through the P2Y

Indexed as

ArteriesConnexinsDiabetes Mellitus, ExperimentalHyperglycemiaMuscle, Smooth, VascularMyocytes, Smooth MuscleNerve Tissue ProteinsVasoconstrictionAdenosine TriphosphateA Kinase Anchor ProteinsAnimalsCalcium Channels, L-TypeCells, CulturedCyclic AMP-Dependent Protein KinasesMaleMiceAdenosine TriphosphateA Kinase Anchor ProteinsCalcium Channels, L-TypeConnexinsCyclic AMP-Dependent Protein KinasesNerve Tissue ProteinsPanx1 protein, mousediseasehyperglycemiaion channelsmuscle, smoothvasoconstriction

Identifiers

PMID40636957
PMCPMC12252251

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.