Evidence map›Paper›PMID 40636976›Full record

ArticleHypertension (Dallas, Tex. : 1979)2025

E-Cigarette Smoke Exposure Elevates Renal MR Expression and Induces BP Elevation.

Jian Wang, Bei Xu, Ying Wang, Jenny Liu, Piwen Wang, Rene Porche, Samuel Kim, Rong Yang, Xuesi M Shao, Kabirullah Lutfy and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jian WangDepartment of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (J.W., R.Y.).
Bei XuDepartment of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (B.X.).
Ying WangDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, CA (Y.W., J.L.).
Jenny LiuDepartment of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, CA (Y.W., J.L.).
Piwen WangDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).
Rene PorcheDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).
Samuel KimDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).
Rong YangDepartment of Pediatrics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, China (J.W., R.Y.).ORCID 0000-0001-6969-8337
Xuesi M ShaoDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).ORCID 0000-0002-5165-347X
Kabirullah LutfyDepartment of Pharmaceutical Sciences, Western University of Health Sciences, Pomona (K.L.).ORCID 0000-0003-0350-3693
Limei LiuDepartment of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, China (L.L.).ORCID 0000-0002-1570-4786
Theodore C FriedmanDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).
Meisheng JiangDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA (M.J.).
Yanjun LiuDivision of Endocrinology, Metabolism and Molecular Medicine, Charles R. Drew University of Medicine and Science and David Geffen School of Medicine at UCLA, Los Angeles, CA (J.W., P.W., R.P., S.K., X.M.S., T.C.F., Y.L.).ORCID 0000-0002-1158-9602

Funding

Drew MIDARP (Infrastructure in Drug Abuse Research)R24DA017298 · NIDA · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI FRIEDMAN, THEODORE C · 2004 to 2018
$5.0M
NIDA NIH HHS R24 DA017298
6 · The paper itself

Abstract

backgroundE-cigarette use increases the risk of blood pressure (BP) elevation in users, though the underlying mechanisms remain unclear. The mineralocorticoid receptor (MR) is known to play an important role in the regulation of renal electrolyte balance and BP, and is protected by 11β-HSD2 (11β-hydroxysteroid dehydrogenase type 2). However, little is known about the effects of renal MR on e-cigarette-induced BP elevation.

methodsC57BL/6J male mice were exposed to aerosolized PBS, e-cigarettes without nicotine, and e-cigarettes with 2.4% nicotine, with concurrent exposure to either a vehicle or the MR antagonist eplerenone.

resultsInhalation of e-cigarettes with nicotine markedly induced renal MR abundance and increased mean arterial BP in response to elevated plasma nicotine levels in C57BL/6J mice. Induction of MR by e-cigarettes was correlated with a reduction in 11β-HSD2 and activation of pSer

conclusionsOur findings highlight the potential renal health damage from e-cigarettes and suggest that aerosol nicotine-mediated induction of MR action in the kidneys may contribute to electronic smoking-induced BP elevation.

Indexed as

Blood PressureElectronic Nicotine Delivery SystemsHypertensionKidneyReceptors, Mineralocorticoid11-beta-Hydroxysteroid Dehydrogenase Type 2AnimalsDisease Models, AnimalEplerenoneMaleMiceMice, Inbred C57BLMineralocorticoid Receptor AntagonistsNicotine11-beta-Hydroxysteroid Dehydrogenase Type 2EplerenoneMineralocorticoid Receptor AntagonistsNicotineReceptors, Mineralocorticoid11β-HSD2blood pressuree-cigaretteeplerenoneGSK3βmineralocorticoid receptornicotine

Identifiers

PMID40636976
PMCPMC12259013

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.