Observational studyJournal of applied physiology (Bethesda, Md. : 1985)2025
Preoperative serum LOXL2 levels are elevated in patients with pulmonary hypertension undergoing mitral valve surgery in a prospective observational cohort study.
Sineád M Nyhan, Mahin Gadkari, Travis Brady, Marta Martinez Yus, Rira Choi, Maria Bauer, Samira Vithani, Joseph Walpole, Allison G Hays, Hamza Aziz and 5 more
Abstract readObservational Study
In one paragraphObservational study in Journal of applied physiology (Bethesda, Md. : 1985), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
15 authors.
Sineád M NyhanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Mahin GadkariDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0002-9214-8656 Travis BradyDepartment of Biomedical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0001-5391-3573 Marta Martinez YusDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, United States.ORCID 0000-0002-5377-3520 Rira ChoiDepartment of Biomedical Engineering, Yale University, New Haven, Connecticut, United States.ORCID 0000-0002-9759-6909 Maria BauerDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-1219-2850 Samira VithaniDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Joseph WalpoleDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-4174-8886 Allison G HaysDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0003-2138-1589 Hamza AzizDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Ahmet KilicDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-2365-3093 Michael RobichDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
James S GammieDivision of Cardiac Surgery, Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.
Lakshmi SanthanamDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0002-2097-9397 Jochen SteppanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.ORCID 0000-0001-9856-512X Funding
Lysyl Oxidase Like 2: A Novel Target in Aging Associated Vascular StiffeningR01HL148112 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI SANTHANAM, LAKSHMI · 2020 to 2023
$1.9MThe Therapeutic Role for LOLX2 in Pulmonary HypertensionK08HL145132 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI STEPPAN, JOCHEN · 2019 to 2023
$859kThrombospondin-1's role in heart failure with preserved ejection fraction (HFpEF)R56HL169285 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI STEPPAN, JOCHEN · 2024 to 2024
$654kHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) K08HL145132HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL148112HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R56HL169285JHH | Department of Anesthesiology and Critical Care Medicine, Johns Hopkins Medicine (JHU ACCM) StAAR Mentored AwardNHLBI NIH HHS K08 HL145132NHLBI NIH HHS R01 HL148112NHLBI NIH HHS R56 HL169285
6 · The paper itselfAbstract
Lysyl oxidase-like 2 (LOXL2) is associated with vascular remodeling associated in pulmonary hypertension (PH). This study evaluates the potential of serum LOXL2 levels as a clinical biomarker. We enrolled 158 patients undergoing mitral valve surgery. Using echocardiographic right ventricular systolic pressures (RVSPs), patients were stratified into those with and without PH preoperative, postoperative, and postdischarge. Healthy volunteers served as a nonsurgical control. Serum LOXL2 concentrations preincision were compared with RVSPs using simple regression and their relationship to PH using one-way ANOVA with Tukey's posttest. Serum LOXL2 concentrations were significantly higher in patients with PH compared with patients without PH (2,718 ± 5,187 pg/mL vs. 640 ± 1,367 g/mL;
Indexed as
Amino Acid OxidoreductasesHypertension, PulmonaryMitral ValveAdultAgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedProspective StudiesAmino Acid OxidoreductasesBiomarkersLOXL2 protein, humanbiomarkercardiac surgerylysyl oxidase-like 2 (LOXL2)pulmonary hypertensionpulmonary hypertension due to left heart disease
Identifiers
PMID40637430
PMCPMC12320476
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