SynthesisClinical research in cardiology : official journal of the German Cardiac Society2026

Impact of GLP-1 receptor agonists on cardiovascular outcomes in heart failure with preserved ejection fraction (HFpEF): systematic review and meta-analysis.

Antony Gonzales-Uribe et al.PubMed ↗Publisher ↗

GLP-1 RAslooks good hereFewer composite of all-cause mortality and HF hospitalization.Randomised, large.

What the trial testedrandomised · 4,043 people · 2026

Randomised vs placebo or other hypoglycemic agents

−27%−40% to −10%

GLP-1 RAs vs placebo or other hypoglycemic agents

Bigger than 8 in 10 for all-cause mortality

As reported

HR 0.73, 95% CI 0.60–0.90

4,043people with heart failure, in this paper

The trial randomly assignedassigned by chance

GLP-1 RAs

placebo or other hypoglycemic agents

Reduced composite of all-cause mortality and HF hospitalization−27%

randomised

the abstract, start to end

… and HF hospitalization by 27% (HR 0.73; 95% CI: 0.60-0.90; I …

← favours treatmentfavours comparator →

could be chance

Composite of all-cause mortality and HF hospitalizationGLP-1 RAs vs placebo or other hypoglycemic agents

HR 0.730.60–0.90

GLP-1 receptor agonistsAll-cause mortality

GLP-1 receptor agonists × all-cause mortalityhelps?replicated

unlikelylikely

0.88not counted

← favours treatmentfavours comparator →

more certainless certain

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2025

2026

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