ReviewExperimental physiology2025
Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction.
Review in Experimental physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Respiratory muscle dysfunction in mechanical ventilation: a systematic review and meta-analysis of biological mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Pooled it
- Assessment of the role of inflammation-linked signaling pathways in ventilator-induced diaphragmatic dysfunction in rats by transcriptome RNA-seq.BMC molecular and cell biology · 2026Article
- New perspectives on the physiological basis of muscle loss.Experimental physiology · 2026Article
- Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction.Experimental physiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Mechanical ventilation (MV) is a life-saving intervention applied to critically ill patients. A common consequence of MV is ventilator-induced diaphragm dysfunction (VIDD), which is characterized by significant diaphragm atrophy and reduced contractile function. Older patients who receive MV are more likely to develop VIDD, have worse recovery, and higher mortality rates compared to younger adults. Despite the greater susceptibility of older adults to develop VIDD and lower survival rates compared to young adults, studies investigating the effects of ageing on VIDD and the recovery from MV are scarce. The field of limb skeletal muscle disuse has extensively shown that compared to adult limb muscles, aged limb muscles respond differently and have blunted recovery after disuse. This review summarizes the literature on the effects of MV on the diaphragm, discussing the available data on the effects of ageing and the recovery process after MV. We also provide an overview of the effects of ageing and the recovery of limb muscle from periods of disuse. We conclude with recommendations for future studies to apply lessons learned from the field of limb muscle disuse to the field of MV and VIDD.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.