Evidence map›Paper›PMID 40639718›Full record

ArticleThe American journal of pathology2025

Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells.

Handan Hong, Taojian Tu, Diala Alhousari, Lina He, Richa Aggarwal, Anketse Debebe, Chien-Yu Chen, Karam Ashouri, Anastasia Martynova, Christina Nakhoul and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Handan HongDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Taojian TuDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Diala AlhousariDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Lina HeDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Richa AggarwalDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Anketse DebebeDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Chien-Yu ChenDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Karam AshouriDivision of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Anastasia MartynovaDivision of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Christina NakhoulDivision of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Ali RastegarpourDivision of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Sina BaharloueiEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California.
Dai PengEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California.
Eileen X StileEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California.
Meisam RazaviyaynEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California; Ming Hsieh Department of Electrical and Computer Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California; Thomas Lord Department of Computer Science, Viterbi School of Engineering, University of Southern California, Los Angeles, California.
Sze-Chuan SuenEpstein Department of Industrial and Systems Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California.
Enrique CadenasDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Houda AlachkarDepartment of Clinical Pharmacy, Mann School of Pharmacy, University of Southern California, Los Angeles, California.
Weiming YuanDepartment of Immunology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Keigo MachidaDepartment of Immunology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Hidekazu TsukamotoDepartment of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California; Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, California.
Liyun YuanDepartment of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Anthony El-KhoueiryDivision of Medical Oncology, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California.
Bangyan L StilesDepartment of Pharmacology and Pharmaceutical Sciences, Mann School of Pharmacy, University of Southern California, Los Angeles, California; Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, California. Electronic address: bstiles@usc.edu.

Funding

The Southernearch Center for ALPD and CirrhosisP50AA011999 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HIDEKAZU TSUKAMOTO · 1999 to 2026
$45.8M
NON-PARENCHYMAL LIVER CELL CORER24AA012885 · NIAAA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TSUKAMOTO, HIDEKAZU · 2001 to 2025
$8.1M
HORMONAL REGULATION OF CONTROL MECHANISMSR01DK013149 · NIDDK · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI GILL, GORDON N · 1986 to 2004
$2.1M
BLRD VA I01 BX001991BLRD VA IK6 BX004205NIAAA NIH HHS P50 AA011999NIAAA NIH HHS R24 AA012885NIDDK NIH HHS R01 DK013149
6 · The paper itself

Abstract

CD5 antigen-like (CD5L) is a multifunctional glycoprotein characterized for its role in the lipid metabolism, particularly within macrophages. In the liver, CD5L strongly correlates with liver injury. This study explored the role of CD5L on liver lipid accumulation and inflammatory response. CD5L promoted lipid uptake in hepatocytes and stellate cells. In multiple models of liver injury, expression of Cd5l was associated with that of Clec4f, a marker for liver macrophages, consistent with its role as a macrophage survival factor. Transwell assay was used to demonstrate a novel function of CD5L on promoting migration of natural killer T cells. This effect was independent of CD36, the characterized receptor of CD5L. This effect was also observed with liver macrophages, which are the cellular source for CD5L, and blocking CD5L attenuated natural killer T cell migration induced by liver macrophages. Finally, plasma levels of CD5L correlated with poor patient response to immune check point therapy that is dependent on response of T-cell populations. In addition, plasma CD5L levels correlated with levels of steatosis and severity of steatotic liver injury. Given the association between liver steatosis and poor response to immune checkpoint therapy, these data suggest that plasma CD5L levels may serve as a predictive biomarker for patient response to immune checkpoint therapy.

Indexed as

Cell MovementKupffer CellsNatural Killer T-CellsAnimalsHumansLiverMaleMiceMice, Inbred C57BL

Identifiers

PMID40639718
PMCPMC12597548

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.