Evidence map›Paper›PMID 40639808›Full record

ArticleJournal of clinical periodontology2025

Association of Periodontal Condition With Serum C-Reactive Protein Levels: The Role of Serum Apolipoproteins' Concentration.

Anniina Haro, Tuomas Saxlin, Anna Liisa Suominen, Antti Jula, Pekka Ylöstalo

Abstract read
In one paragraph

Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anniina HaroInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.ORCID 0009-0003-3360-6877
Tuomas SaxlinInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-6855-7425
Anna Liisa SuominenInstitute of Dentistry, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-8543-0055
Antti JulaNational Institute for Health and Welfare (THL), Turku, Finland.ORCID 0000-0002-3522-5301
Pekka YlöstaloResearch Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-1957-7577

Funding

Finnish Association of Women DentistsSuomen Hammaslääkäriseura Apollonia
6 · The paper itself

Abstract

aimTo investigate whether the systemic inflammatory response against inflammatory conditions in the periodontium is related to serum apolipoprotein B (ApoB) and A1 (ApoA1) concentrations. MATERIAL AND

methodsThe study consisted of the Health 2000 Survey participants (n = 2709) aged 30-49 years. The inflammatory condition of the periodontium was assessed by means of the number of teeth with deepened (≥ 4 mm) and deep (≥ 6 mm) periodontal pockets. Systemic inflammation was measured by serum C-reactive protein (CRP) levels. The role of ApoB and ApoA1 was studied by performing regression analyses and stratified analyses (according to the median values).

resultsIn logistic regression analyses, the number of teeth with deepened (≥ 4 mm) periodontal pockets was associated with serum CRP levels among those participants whose serum ApoB concentration was ≥ 1.12 g/L. When the participants' ApoB concentration was < 1.12 g/L, such an association between deepened periodontal pockets and CRP was not observed. The direction or strength of the association between periodontal pockets and CRP was not essentially different in the ApoA1 strata.

conclusionSystemic response against poor periodontal condition varied between individuals. The variation appeared to be related more to the serum concentration of ApoB than ApoA1.

Indexed as

Apolipoprotein A-IApolipoproteins BC-Reactive ProteinPeriodontal PocketAdultFemaleHumansMaleMiddle AgedApolipoprotein A-IApolipoproteins BC-Reactive Proteinapolipoproteinsgingivitislipidsperiodontal diseasesperiodontitis

Identifiers

PMID40639808
PMCPMC12420079

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.