ArticleJournal of neurointerventional surgery2026
Outcomes of endovascular thrombectomy in acute ischemic stroke patients with insulin resistance.
Article in Journal of neurointerventional surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- The C-Reactive Protein-Triglyceride-Glucose Index and Functional Outcomes in Acute Ischemic Stroke Patients Following Endovascular Thrombectomy.Brain and behavior · 2026Article
- Association between the triglyceride-glucose index and collateral status in ischemic stroke patients undergoing endovascular therapy.Clinical neuroradiology · 2026Article
- Association of the Triglyceride-Glucose (TyG) Index and TyG-BMI With 1-Year Outcomes Following Endovascular Treatment in Acute Basilar Artery Occlusion.CNS neuroscience & therapeutics · 2026Article
- Triglyceride-glucose index as a potential evaluation tool for all-cause mortality in ischemic stroke patients undergoing endovascular therapy: a multicenter cohort study.BMC endocrine disorders · 2026Observational
- Effect of TyG index on endovascular therapy in large vessel occlusion stroke with different etiologies.BMC neurology · 2026Article
- Systemic immune-inflammation index, stress hyperglycemia ratio and triglyceride-glucose index in acute ischemic stroke: an integrated inflammation-stress-metabolism perspective.Frontiers in neurology · 2026Review
- Association of the single point insulin sensitivity estimator index with functional outcomes and hemorrhagic transformation in patients with acute ischemic stroke.Frontiers in nutrition · 2026Article
- Association of the triglyceride-glucose index with the severity and short-term prognosis of Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Association of insulin resistance indices with outcomes after endovascular treatment in acute basilar artery occlusion.Lipids in health and disease · 2025Article
- The triglyceride-glucose index: updating evidence from clinical settings to molecular mechanisms in ageing-related cerebrovascular diseases.Cardiovascular diabetology · 2025Review
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10 authors.
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Abstract
backgroundFor patients with acute ischemic stroke (AIS) caused by large vessel occlusion, endovascular thrombectomy (EVT) serves as the standard treatment. However, a significant proportion of patients fail to achieve functional independence despite successful recanalization. While insulin resistance (IR) has been implicated in adverse stroke outcomes, its precise impact on AIS patients undergoing EVT remains incompletely characterized.
methodsThis multicenter cohort study acquired data from the RESCUE-RE registry to explore the association between IR, quantified via the triglyceride glucose (TyG) index, and 90-day functional outcomes in AIS patients undergoing EVT. The primary outcome was functional dependence, defined as a modified Rankin Scale score ≥3 at 90 days. Secondary outcomes included symptomatic intracranial hemorrhage, all-cause mortality, early neurological deterioration, and infarct volume at 24 hours, as assessed by follow-up imaging.
resultsAmong 1305 patients, higher TyG index quartiles were notably associated with unfavorable clinical outcomes. Patients with the highest TyG quartile (Q4) exhibited increased odds of functional dependence (adjusted odds ratio (aOR) 1.79, 95% confidence interval (95% CI) 1.26 to 2.54), early neurological deterioration (aOR 2.48, 95% CI 1.46 to 4.22), and mortality (OR 2.62, 95% CI 1.68 to 4.09) compared with those with the lowest TyG quartile (Q1). Stratified analyses revealed that these associations were more pronounced in younger patients, females, and individuals with hypertension, diabetes, and favorable collateral circulation. Mediation analyses identified inflammation as a partial explanatory factor in the observed relationships.
conclusionsInsulin resistance is independently associated with deteriorated functional outcomes in AIS patients undergoing EVT.
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