Evidence map›Paper›PMID 40639999›Full record

ArticleTrends in neurosciences2025

Hypothalamic prolactin signaling protects against overheating in pregnancy.

Laura R Cortes, Stephanie M Correa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in neurosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura R CortesDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90077, USA. Electronic address: lauracortes@ucla.edu.
Stephanie M CorreaDepartment of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90077, USA. Electronic address: stephaniecorrea@ucla.edu.

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA LIFT-UP (Leveraging Institutional support For Talented, Upcoming Physicians and/or Scientists)U24DK132746 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI OBIDIUGWU KENRIK DURU, CAROL M MANGIONE · 2022 to 2026
$3.2M
Estrogenic modulation of neural circuits that control temperatureR01AG066821 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORREA, STEPHANIE · 2020 to 2024
$2.1M
Hypothalamic gating of the anorexic effects of estradiolR01DK136073 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Stephanie Correa · 2023 to 2026
$2.0M
The neural control of thermoregulatory changes accompanying pregnancyK00HD109205 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CORTES, LAURA · 2022 to 2025
$324k
NCATS NIH HHS UL1 TR001881NIA NIH HHS R01 AG066821NICHD NIH HHS K00 HD109205NIDDK NIH HHS R01 DK136073NIDDK NIH HHS U24 DK132746
6 · The paper itself

Abstract

Pregnancy involves physiological adaptations that optimize fetal development. Reduced maternal core temperature may protect offspring from the teratogenic effects of excess heat, but the mechanisms regulating body temperature during pregnancy remained largely unclear. In a recent study in mice, Ladyman and colleagues identified the prolactin receptor (Prlr) as a thermal switch lowering maternal core temperature and promoting offspring survival in warm environments.

Indexed as

HypothalamusProlactinSignal TransductionAnimalsFemaleHumansMicePregnancyReceptors, ProlactinProlactinReceptors, Prolactinhormonematernal careoffspring survivalpreoptic areathermoregulationwarmth

Identifiers

PMID40639999
PMCPMC12363340

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.