ArticleNPJ Parkinson's disease2025
Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease.
Article in NPJ Parkinson's disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Reply to: Bridging predictive algorithms and clinical practice in DBS contact selection.NPJ Parkinson's disease · 2026Article
- Multitarget brain implants enable generalized decoding of Parkinson's disease symptoms from chronic home recordings.Research square · 2026Article
- Beta-Band and Aperiodic Activity Across New and Chronic Subthalamic Nucleus Deep Brain Stimulation in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Local field potentials survey to guide DBS programming in Parkinson's disease: a clinical-neurophysiological longitudinal study.NPJ Parkinson's disease · 2025Article
- Chronic adaptive deep brain stimulation for Parkinson's disease: clinical outcomes and programming strategies.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Beta oscillations (±13-35 Hz) and aperiodic spectral features extracted from local field potential (LFP) recordings have been identified as promising physiomarkers for adaptive deep brain stimulation (aDBS) in Parkinson's disease. However, the long-term consistency of these signal features across behavioural and clinical conditions remains unclear. Bilateral subthalamic nucleus LFPs were recorded from twelve patients with an average inter-recording interval of 137 days, during rest, a finger-to-nose task and speech, with stimulation switched off and on. Intra-class correlation coefficients indicated moderate between-visit consistency for aperiodic offset and exponent but good to excellent consistency of beta peak power. Most aperiodic and power changes induced by task execution and stimulation were statistically comparable across visits. Results remained inconclusive regarding the properties of beta peaks exhibiting the strongest power suppression post-stimulation. Our findings support the potential of beta peak power as primary physiomarker for aDBS, with aperiodic components as possibly suitable supplementary markers.
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Registered trials
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