ArticleNPJ science of food2025
Deep learning to assess erythritol in zebrafish development, circadian rhythm, and cardiovascular disease risk.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Circadian clock regulation of hemostasis: a systematic review of molecular pathways.Research and practice in thrombosis and haemostasis · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Erythritol is one of the most widely used artificial sweeteners, yet the potential risks remain a subject of debate. In this experiment, the concentration of erythritol was determined according to pre-experiments (3, 5, 7 mg/mL), and exposure was initiated at 2 h post-fertilization of embryonic development until the end of 120 hpf. Here, we employed a deep learning approach to uncover the time and tempo aspects of embryonic development. Erythritol may contribute to motor behavioral impairments in larvae by delaying the development of the swim bladder. Furthermore, erythritol causes circadian rhythm disorder and affects the expression of the rev-erba, which leads to thrombus formation. The formation of thrombi is accompanied by oxidative stress and inflammation. The above findings contribute to the understanding of the effects of erythritol on zebrafish development, neurobehavior, and cardiovascular disease and provide a basis for the safety of erythritol as an artificial sweetener.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.