ArticleScientific reports2025
The triangular relationship of serum uric acid, osteoporosis or osteopenia, and body mass index for men and postmenopausal women.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of body mass index and bone mineral density in postmenopausal women: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- A Novel Approach to Determining Bone Loss Through Serum Uric Acid Levels: A Retrospective Multicenter Cohort Analysis.Journal of clinical medicine · 2026Article
- Association between serum uric acid levels and lumbar spine Z-scores in adults aged <50 years: A cross-sectional study.Metabolism open · 2026Article
- Development of a machine learning-based predictive model for osteoporosis risk and its application in clinical decision support.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Osteoporosis (OP) is a systemic bone disease characterized by reduced bone density and quality, leading to increased bone fragility and a higher risk of fractures. The relationship between serum uric acid (SUA) levels and OP or osteopenia remains controversial, as does the impact of weight change on these conditions. Moreover, few studies have investigated whether body mass index (BMI) serves as a mediator in the association between SUA and OP or osteopenia. This study aimed to elucidate the complex interactions between SUA, OP or osteopenia, and BMI. A cross-sectional study from the REACTION study was conducted to examine the association between SUA and OP or osteopenia. Various logistic regression and restricted cubic spline models were employed to analyze the pairwise correlations among these variables, and interaction analysis was performed to assess differences between subgroups. Mediation models were utilized to determine the mediating role of BMI. A cross-sectional study from the REACTION study was conducted to examine the association between SUA and OP or osteopenia. Various logistic regression and restricted cubic spline models were employed to analyze the pairwise correlations among these variables, and interaction analysis was performed to assess differences between subgroups. Mediation models were utilized to determine the mediating role of BMI. In female-dominated populations, SUA appears to have a protective effect against OP or osteopenia, with BMI potentially serving as a partial mediator. Thereby, maintaining SUA and BMI within an optimal range may help reduce the risk of OP or osteopenia.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.