Evidence map›Paper›PMID 40640339›Full record

ArticleCommunications biology2025

Mineralocorticoid receptor knockout alters hippocampal CA2 neurons to become like those in CA1.

Erin P Harris, Başak Kandemir, Stephanie M Jones, Georgia M Alexander, James M Ward, TianYuan Wang, Stephanie Proaño, Xin Xu, Serena M Dudek

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A modifiable driver of dementia: cognitive impairment in primary aldosteronism.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Erin P Harris *Neurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Başak Kandemir *Neurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0003-1909-5778
Stephanie M JonesNeurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Georgia M AlexanderNeurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
James M WardIntegrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
TianYuan WangIntegrative Bioinformatics Support Group, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Stephanie ProañoNeurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.
Xin XuEpigenetics and Stem Cell Biology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA.ORCID http://orcid.org/0000-0003-2294-0047
Serena M DudekNeurobiology Laboratory, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, USA. dudek@niehs.nih.gov.ORCID http://orcid.org/0000-0003-4094-8368

Funding

Synaptic Plasticity In The Adult And Developing NSZ01ES100221 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI DUDEK, SERENA M · 2002 to 2008
$3.5M
Intramural NIH HHS Z01 ES100221U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS) ES100221
6 · The paper itself

Abstract

Hippocampal area CA2 has emerged as a functionally and molecularly distinct part of the hippocampus and is necessary for several types of social behavior including social aggression. As part of the unique molecular profile of both mouse and human CA2, the mineralocorticoid receptor (MR; Nr3c2) appears to play a critical role in controlling CA2 neuron cellular and synaptic properties. To better understand the fate (or state) of the neurons resulting from MR conditional knockout, we use a spatial transcriptomics approach. We find that without MRs, 'CA2' neurons acquire a CA1-like molecular phenotype. Additionally, we find that neurons in this area appear to have a cell size and density more like that in CA1. These findings support the idea that MRs control CA2's 'state', at least during development, resulting in a CA1-like 'fate'.

Indexed as

CA1 Region, HippocampalCA2 Region, HippocampalNeuronsReceptors, MineralocorticoidAnimalsMaleMiceMice, KnockoutTranscriptomeReceptors, Mineralocorticoid

Identifiers

PMID40640339
PMCPMC12246475

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.