Evidence map›Paper›PMID 40640358›Full record

ArticleScientific reports2025

Microglial exosome TREM2 ameliorates ferroptosis and neuroinflammation in alzheimer's disease by activating the Wnt/β-catenin signaling.

Ling Zhu, Tao Zhou, Lei Wu, Xuanang Zhu, Lvan Chen, Mi Zhang, Jing Zhou, Fan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

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  6. Neurotransmitter Systems in Alzheimer's Disease.Current issues in molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ling ZhuDepartment of Neurology, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Tao ZhouDepartment of Emergency, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Lei WuDepartment of Neurology, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Xuanang ZhuDepartment of Neurology, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Lvan ChenDepartment of Neurosurgery, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Mi ZhangDepartment of Neurology, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China.
Jing ZhouCollege of Medical, Jingchu University of Technology, Jingmen, 448000, China. 200707023@jcut.edu.cn.
Fan WangDepartment of Neurosurgery, Jingmen Central Hospital, Jingmen Central Hospital, Jingchu University of Technology, Jingmen, 448000, China. wang.fan1984@outlook.com.

Funding

Health Commission of Hubei Province WJ2023M171Hubei Provincial Department of Education research project B2023223 and D20234302Hubei Provincial Natural Science Foundation General Project 2024AFB1021Key Science and Technology Plan Project of Jingmen 2024YFZD063, 2018YFZD025, and 2023YFZD006
6 · The paper itself

Abstract

Microglia and exosomes are intimately connected with the pathogenesis of Alzheimer's disease (AD). We aim to investigate the role and potential mechanisms of M2-like (anti-inflammatory) microglia-derived exosomes (M2-Exos) in AD. We utilized an Aβ

Indexed as

Alzheimer DiseaseExosomesFerroptosisMembrane GlycoproteinsMicrogliaNeuroinflammatory DiseasesReceptors, ImmunologicWnt Signaling PathwayAmyloid beta-PeptidesAnimalsbeta CateninCell LineDisease Models, AnimalHumansInflammationMaleAmyloid beta-Peptidesbeta CateninMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseAlzheimer’s diseaseExosomesFerroptosisM2-like microgliaTREM2Wnt/β-catenin pathway

Identifiers

PMID40640358
PMCPMC12246186

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.