Evidence map›Paper›PMID 40640372›Full record

ArticleCommunications medicine2025

The treatment of primary CoQ deficiency requires the targeting of multiple pathogenic mechanisms.

Pilar González-García, Laura Jiménez-Sánchez, Julia Corral-Sarasa, Sergio López-Herrador, Sara Torres-Rusillo, María Elena Díaz-Casado, Luis C López

Abstract read
In one paragraph

Article in Communications medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Bypass Treatments for Primary Coenzyme Q10 Deficiency: An Update.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Pilar González-GarcíaDepartamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.ORCID http://orcid.org/0000-0002-9560-2957
Laura Jiménez-SánchezDepartamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.
Julia Corral-SarasaInstituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.
Sergio López-HerradorDepartamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.
Sara Torres-RusilloInstituto de Biotecnología, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain.
María Elena Díaz-CasadoDepartamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain.
Luis C LópezDepartamento de Fisiología, Facultad de Medicina, Universidad de Granada, Granada, Spain. luisca@ugr.es.ORCID http://orcid.org/0000-0003-3355-0298

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary coenzyme Q (CoQ) deficiency is a severe mitochondrial disorder characterized by diverse clinical manifestations due to multiple pathomechanisms. Although CoQ

methodsIn this study, we investigated the therapeutic potential of combining CoQ

resultsIn Coq9

conclusionsOur findings demonstrate that combining CoQ

Identifiers

PMID40640372
PMCPMC12246469

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.