ArticleScientific reports2025
3D printed bone nails loaded with ceftriaxone sodium for localized drug delivery.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The convergence of advanced materials science and additive manufacturing technologies has revolutionized medical applications ranging from orthodontic devices to patient-specific bone fixation systems. Despite these advancements, the clinical translation of 3D-printed orthopedic implants remains constrained by suboptimal biocompatibility of conventional manufacturing materials. This study systematically evaluates dental resin-based composites as alternative biomaterials for bone fixation devices, hypothesizing that their rapid photopolymerization kinetics, mechanical robustness, and inherent biocompatibility can address current limitations. Through stereolithography technology, ceftriaxone sodium-loaded bone fixation devices were developed with customized geometries tailored to diverse anatomical requirements. Material optimization revealed that a 7:3 ratio of ethoxylated bisphenol A dimethacrylate (BPA2EODMA) to triethylene glycol dimethacrylate (TEGDMA) achieved optimal mechanical performance. Cytocompatibility assessment using L929 fibroblasts demonstrated > 70% cell viability, confirming minimal cytotoxicity. The drug-eluting implants exhibited potent antimicrobial efficacy in 8-h elution assays, showing inhibition rates of 49.14 ± 4.89% (Staphylococcus aureus), 48.38 ± 5.88% (Escherichia coli), and 26.79 ± 2.69% (Candida albicans). These results validate the dual functionality of antibiotic-loaded dental resin constructs, positioning them as promising candidates for patient-specific orthopedic solutions that simultaneously address mechanical stability, osseointegration, and infection prevention.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.