ArticleScientific reports2025
Interplay of kidney function and anti-SARS-CoV-2 antibodies in COVID-19 mortality: a prospective cohort study.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Temporal Evolution of the Impact of CKD on COVID-19 Outcomes : A 5-Year Nationwide Analysis.Kidney360 · 2026Article
- Association between hypertension and risk of respiratory failure and mortality in patients with COVID-19: a retrospective cohort study with predictive model development.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CKD has been recognized as an independent risk factor for severe disease and death in COVID-19. Given the high variability in humoral responses, their general decrease in strength, quality, and durability with age, and the decline of antibody levels over time, personalized vaccination regimes would ensure optimal protection of patients with CKD. This prospective, multicenter cohort study included 1112 hospitalized COVID-19 patients from five study centers. Anti-SARS-CoV-2-spike antibodies and eGFR were measured on hospital admission. The primary outcome was all-cause in-hospital mortality. Reduced kidney function combined with anti-SARS-CoV-2 spike antibody levels was a stronger predictor of COVID-19 mortality than either parameter separately. After adjusting for potential confounders, patients with an eGFR of 60-89 ml/min, 30-59 ml/min, and < 30 ml/min had 4.5, 8.5, and 8.4 times higher odds of dying if antibody levels were below the Youden index of 182BAU/ml (aOR 4.468, 95%CI 1.599-12.486, p = 0.004; 8.528, 3.190-22.793, p < 0.001; 8.400, 2.571-27.442, p < 0.001). Mortality rates did not differ significantly by renal function in CKD patients with antibody levels > 1200BAU/ml. In patients with impaired kidney function, survival is strongly associated with sufficiently high antibody levels. Additional booster vaccinations should be considered in CKD patients with antibody levels < 1200BAU/ml.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.