ArticleBritish journal of cancer2025
A study of subjective memory impairment in long-term testicular cancer survivors.
Article in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMemory impairment is a common late adverse effect in survivors of many cancer types, but there are few studies of long-term survivors of testicular cancer (LTCSs). The aims of this study were to examine memory impairment in LTCSs both longitudinally and cross-sectionally, and to compare the cross-sectional findings with normative data.
methodsA national sample of 753 LTCSs filled in questionnaires at means of 12 and 28 years after diagnosis. Memory impairment was reported by the Meta-Memory Questionnaire at 28 years. Longitudinal and cross-sectional associations between independent variables and memory impairment were examined with linear regression analyses.
resultsAt 28 years mean memory impairment scores in LTCSs hardly differed from normative values in 10-year age groups from 40 to 79 years. Many variables were significantly associated with memory impairment in univariate regression analyses both cross-sectionally and longitudinally. In multivariable analyses total fatigue was significantly associated with memory impairment longitudinally, and with total fatigue and increased neuropathy cross-sectionally.
conclusionsLTCSs at 28 years since diagnosis do not have increased level of memory impairment compared to normative data. In case of memory impairment complaints in LTCSs, several risk factors should be examined and some of them are amenable to interventions.
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