Evidence map›Paper›PMID 40640575›Full record

ArticleNPJ digital medicine2025

How machine learning on real world clinical data improves adverse event recording for endoscopy.

Stefan Wittlinger, Isabella C Wiest, Mahboubeh Jannesari Ladani, Jakob Nikolas Kather, Matthias P Ebert, Fabian Siegel, Sebastian Belle

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Augmenting Electronic Health Records for Adverse Event Detection.medRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stefan Wittlinger *Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Isabella C Wiest *Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Mahboubeh Jannesari LadaniDepartment of Biomedical Informatics, Mannheim Institute for intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jakob Nikolas KatherElse Kroener Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
Matthias P EbertDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Fabian SiegelDepartment of Biomedical Informatics, Mannheim Institute for intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sebastian BelleDepartment of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Sebastian.belle@umm.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endoscopic interventions are essential for diagnosing and treating gastrointestinal conditions. Accurate and comprehensive documentation is crucial for enhancing patient safety and optimizing clinical outcomes; however, adverse events remain underreported. This study evaluates a machine learning-based approach for systematically detecting endoscopic adverse events from real-world clinical metadata, including structured hospital data such as ICD-codes and procedure timings. Using a random forest classifier detecting adverse events perforation, bleeding, and readmission, we analysed 2490 inpatient cases, achieving significant improvements over baseline prediction accuracy. The model achieved AUC-ROC/AUC-PR values of 0.9/0.69 for perforation, 0.84/0.64 for bleeding, and 0.96/0.9 for readmissions. Results highlight the importance of multiple metadata features for robust predictions. This semi-automated method offers a privacy-preserving tool for identifying documentation discrepancies and enhancing quality control. By integrating metadata analysis, this approach supports better clinical decision-making, quality improvement initiatives, and resource allocation while reducing the risk of missed adverse events in endoscopy.

Identifiers

PMID40640575
PMCPMC12246240

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.