Evidence map›Paper›PMID 40640832›Full record

ArticleRespiratory research2025

Nocturnal hypoxemia is associated with poor pulmonary hemodynamics in patients with chronic thromboembolic pulmonary disease.

Teng Han, Qiang Huang, Zhenguo Zhai, Xiaolei Zhang

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Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Teng HanNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Qiang HuangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China.
Zhenguo ZhaiNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China. zhaizhenguo2011@126.com.
Xiaolei ZhangNational Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P.R. China. yutian728@sina.com.

Funding

CAMS Innovation Fund for Medical Sciences(CIFMS) 2022-I2M-1-025National High Level Hospital Clinical Research Funding 2023-NHLHCRF-YYPPLC-TJ-23
6 · The paper itself

Abstract

backgroundAlthough a general association between nocturnal hypoxemia or sleep-disordered breathing (SDB) and pulmonary arterial hypertension has been established, little is known about the unique pathophysiologic contributions of SDB and nocturnal hypoxemia to chronic thromboembolic pulmonary disease (CTEPD). We therefore chose to examine the associations of SDB and nocturnal hypoxemia with hemodynamic indices obtained via right heart catheterization (RHC) in hospitalized patients with CTEPD. We hypothesized that the severity of CTEPD would be associated with SDB and nocturnal hypoxemia severity.

methodsPatients with CTEPD with or without pulmonary hypertension (PH) who had undergone polysomnography (PSG) between July 2022 and March 2024 were enrolled. A nocturnal mean oxygen saturation by pulse oximetry (MeanSpO

resultsThe prevalence of severe nocturnal hypoxemia in the entire cohort was 42.86%, and SDB (AHI ≥ 15/h) affected 55.84% of patients and was predominantly manifested as hypopnea. Nocturnal hypoxemia remained significantly associated with mean pulmonary artery pressure (mPAP) (T90: β = 0.296, P = 0.019; MeanSpO

conclusionsSDB is highly prevalent in patients with CTEPD, which is predominantly manifested as hypopnea rather than apnea, and overweight is not a commonly reported characteristic. Independent of the severity of SDB, nocturnal hypoxemia is significantly correlated with hemodynamics in patients with CTEPD, which indicated the clinical necessity of promoting nocturnal oximetry monitoring among patients with CTEPD.

Indexed as

HemodynamicsHypertension, PulmonaryHypoxiaPulmonary EmbolismSleep Apnea SyndromesAgedCardiac CatheterizationChronic DiseaseCohort StudiesFemaleHumansMaleMiddle AgedOximetryOxygen SaturationPolysomnographyChronic thromboembolic pulmonary diseaseNocturnal hypoxemiaPulmonary hemodynamicsSleep-disordered breathing

Identifiers

PMID40640832
PMCPMC12243409

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