ArticleCardiovascular diabetology2025
Association between modified triglyceride glucose indices and stroke risk in middle-aged and older Chinese adults: a prospective cohort study.
Article in Cardiovascular diabetology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations of triglyceride-glucose-related composite obesity indices with cardiovascular diseases and mortality: a systematic review and meta-analysis.Cardiovascular diabetology · 2026Pooled it
- Combined effect of the triglyceride-glucose index and frailty index on advanced stages among cardiovascular-kidney-metabolic syndrome patients.Journal of cardiothoracic surgery · 2026Article
- Joint association of triglyceride-glucose index and atherogenic lipid markers with incident stroke risk.Scientific reports · 2026Article
- Differential associations between novel triglyceride-glucose-obesity indices and incident stroke in individuals with early-stage cardiovascular-kidney-metabolic syndrome: a longitudinal cohort study.Cardiovascular diabetology · 2026Article
- Combined effects of cumulative triglyceride-glucose and blood pressure on stroke in middle-aged and older Chinese adults: a longitudinal analysis.Journal of global health · 2026Article
- Association between the triglyceride-high-density lipoprotein-glucose-body index and new-onset stroke risk: a prospective cohort study.Lipids in health and disease · 2026Article
- Short-term trajectories of TyG-WHtR and hs-CRP and their joint impact on stroke risk in early CKM syndrome: evidence from Chinese national cohort.Scientific reports · 2026Article
- Joint association of triglyceride-glucose (TyG) and atherogenic index of plasma (AIP) with stroke risk: findings from a nationwide prospective cohort.Cardiovascular diabetology · 2026Article
- Development and Validation of a Prognostic Nomogram for Post-Transcatheter Aortic Valve Replacement Heart Failure Hospitalization in Patients With Concurrent Symptomatic Aortic Stenosis and Heart Failure With Preserved Ejection Fraction: A Multicenter Study.Journal of the American Heart Association · 2026Article
- Comprehensive evaluation of triglyceride glucose index-a body shape index (TyG-ABSI) for incident peripheral artery disease: data-driven phenotyping and machine learning-based risk prediction in the UK Biobank.Cardiovascular diabetology · 2026Article
- Association of the triglyceride-glucose-body mass index with all-cause mortality in critically ill patients with hemorrhagic stroke: a retrospective cohort study from the MIMIC-IV database.Neurosurgical review · 2026Article
- Association of pericoronary fat attenuation index and insulin resistance for the risk of cardiometabolic multimorbidity: a cross-sectional study.Frontiers in endocrinology · 2026Article
- Dissecting the pathogenic effects of ambient air pollution exposure and its blood DNA methylation markers on cardiovascular disease risk.Clinical epigenetics · 2025Article
- Associations of cumulative exposure and dynamic trajectories of the C-reactive protein-triglyceride-glucose index with incident stroke in middle-aged and older Chinese adults: a longitudinal analysis based on CHARLS.Cardiovascular diabetology · 2025Article
- Association between the LDL/HDL ratio and sarcopenia in Chinese community-dwelling older adults.PloS one · 2025Article
- The inflammatory index and cytokines are associated with non-alcoholic fatty liver disease in type 2 diabetes mellitus.Frontiers in medicine · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
objectiveVarious modified triglyceride and glucose (TyG) indices have been proposed, but the literature on the impact and ability of the modified TyG index to predict stroke disease remains limited. We aimed to investigate the associations between the modified TyG indices and incident stroke diseases and to compare their predictive power in a nationally representative cohort.
methodsThis was a prospective cohort study with longitudinal data from the China Health and Retirement Longitudinal Study (CHARLS), which was based on data from four CHARLS surveys in 2011, 2013, 2015 and 2018, and included a total of 8677 participants. The Cox proportional risk model, Restricted Cubic Spline (RCS), and Receiver Operating Characteristic curve (ROC) were analyzed for the associations of TyG-BMI, TyG-WC and TyG-WHtR with stroke risk. In addition, the robustness of the findings was further validated using a series of sensitivity analyses and subgroup analyses.
resultsDuring the follow-up period from 2011 to 2018, 807 (9.3%) of the 8677 participants experienced stroke. After multifactorial adjustment (Model III), a 10-unit increase in TyG-BMI corresponded to a 5.5% increased risk of stroke (HR = 1.055, 95% CI 1.033-1.078), a 10-unit increase in TyG-WC corresponded to a 2.0% increased risk of stroke (HR = 1.020, 95% CI 1.012-1.027), and a 1-unit increase in TyG-WHtR corresponded to a 32.4% increased risk of stroke (HR = 1.324, 95% CI 1.178-1.487). Compared with individuals in the lowest quartile (Q
conclusionsIn middle-aged and elderly populations, TyG-BMI, TyG-WC and TyG-WHtR are positively correlated with the risk of stroke. Maintaining favorable levels of these indices through weight and waist management may help reduce stroke risk.
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