Evidence map›Paper›PMID 40641284›Full record

ArticleChemistryOpen2025

Synthesis, Anticancer Evaluation, and Molecular Docking of Novel Thiazolobenzimidazole-Thiazole Hybrids as Potent Colon Cancer Inhibitors.

Bader Huwaimel, Amr S Abouzied, Magdi E A Zaki, Abdulwahab Alamri, Basant Farag, Saad Alqarni, Sobhi M Gomha

Abstract read
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bader HuwaimelDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, 55473, Saudi Arabia.
Amr S AbouziedDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, 55473, Saudi Arabia.
Magdi E A ZakiDepartment of Chemistry, Faculty of Science, Imam Mohammed Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia.ORCID 0000-0002-5643-9202
Abdulwahab AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Ha'il, Ha'il, 55211, Saudi Arabia.
Basant FaragDepartment of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Saad AlqarniDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha'il, Ha'il, 55473, Saudi Arabia.
Sobhi M GomhaDepartment of Chemistry, Faculty of Science, Islamic University of Madinah, Madinah, 42351, Saudi Arabia.ORCID 0000-0002-7739-2837

Funding

Scientific Research Deanship at University of Ha'il - Saudi Arabia RG-24 152
6 · The paper itself

Abstract

In this study, a series of novel benzimidazothiazole-thiazole hybrids is synthesized via the condensation of 2-(1-(3-methylbenzoimidazo[2,1-b]thiazol-2-yl)ethylidene)hydrazine-1-carbothioamide with various hydrazonoyl halides and α-halo compounds. Structural elucidation is confirmed by infrared, nuclear magnetic resonance (NMR), mass spectrometry (MS), and elemental analysis. The anticancer activities of the synthesized compounds are assessed against the HCT-116 colon carcinoma cell line using the MTT assay, where compound 16b exhibits the strongest cytotoxic effect (IC

Indexed as

Antineoplastic AgentsBenzimidazolesColonic NeoplasmsMolecular Docking SimulationThiazolesCell ProliferationDrug Screening Assays, AntitumorHCT116 CellsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsBenzimidazolesThiazolesADMET profiling.anticancer activitybenzimidazothiazolesHCT‐116hydrazonoyl chloridesmolecular dockingthiazoles

Identifiers

PMID40641284
PMCPMC12598833

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.