ArticleAnimal models and experimental medicine2025
Harnessing the multidimensional bioactivity of Chaetomorpha aerea: Integrative phytochemical profiling with in vitro, in vivo, and in silico insights.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Bioactivity Assessment and In Silico Target Engagement ofFood science & nutrition · 2026Article
- Bioactive Composition and Antioxidant and Glycemic-Regulating Properties ofFood science & nutrition · 2026Article
- Seaweed bioactives: A comprehensive review of their nutritional, medicinal, and functional roles.iScience · 2026Review
- Wound-Healing Efficacy ofFood science & nutrition · 2026Article
- Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti-inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies.Animal models and experimental medicine · 2026Article
- Acute and Subacute Oral Toxicity Evaluation ofFood science & nutrition · 2026Article
- Exploring the Anti-Nociceptive, Anti-Inflammatory, Anti-Pyretic, and Anti-Arthritic Activity of Methanolic Extract ofAdvances in pharmacological and pharmaceutical sciences · 2026Article
- Pharmacological and Computational Insights Into the Analgesic, Antipyretic, and Antidiarrheal Potential ofTheScientificWorldJournal · 2026Article
- Harnessing the multidimensional bioactivity of Chaetomorpha aerea: Integrative phytochemical profiling with in vitro, in vivo, and in silico insights.Animal models and experimental medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChaetomorpha aerea, a marine green alga, has drawn attention because of its rich phytochemical constituents and therapeutic benefits. Using an integrated approach that combined in vitro, in vivo, and in silico approaches, this work examined the antioxidant, anti-inflammatory, and antidiabetic qualities of acetone extract of C. aerea (AECA).
methodsTotal phenolic and flavonoid concentrations of AECA were measured. Antioxidant activity was assessed using the DPPH and ABTS free radical scavenging assays. In vitro protein denaturation and in vivo carrageenan-induced paw edema models were employed to evaluate the anti-inflammatory potential, whereas antidiabetic activity was assessed using in vitro α-amylase inhibition and in vivo oral glucose tolerance test (OGTT). Molecular docking and ADME/T analysis were employed to further analyze bioactive compounds identified using gas chromatography-mass spectrometry (GC-MS).
resultAntioxidant activity demonstrated a minimum inhibitory concentration (IC
conclusionC. aerea serves as an effective natural remedy for oxidative stress, inflammation, and hyperglycemia. These findings advocate for further clinical and mechanistic investigations to optimize therapeutic efficacy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.